Background Aggregated α-synuclein plays an important role in the pathogenesis of Parkinson’s
disease. The monoclonal antibody prasinezumab, directed at aggregated α-synuclein, is …

Background Multiple system atrophy (MSA) is a neurodegenerative condition characterized
by variable combinations of parkinsonism, autonomic failure, cerebellar ataxia and …

The non-human primate MPTP model of Parkinson's disease is an essential tool for translational
studies. However, the currently used methodologies to produce parkinsonian monkeys …

The objective of this study was to assess cardiovascular response during cardiac stress testing
in neurologically asymptomatic individuals who developed motor features of Parkinson's …

Background and objective. Mutations in the Leucine‐Rich Repeat Kinase 2 (LRRK2) gene
at chromosome 12q12 are the most common genetic cause of sporadic and familial late‐…

… Fernandez-Torron R,… Domínguez C, Vieites-Prado A, Pérez-Mato M, Sobrino T,
Rodríguez-Osorio X, López A, Campos F, Martínez F, Castillo J, Leira R … Pagola I, Esteve-Belloch …

Much controversy exists concerning the effect of levodopa on striatal dopaminergic markers
in Parkinson's disease (PD) and its influence on functional neuroimaging. To deal with this …

Several in vitro and in vivo findings have consistently shown that α-synuclein derived from
multiple system atrophy (MSA) subjects has more seeding capacity than Parkinson’s disease-…

Whipple disease (WD) is a rare, multisystem infectious disease caused by the Gram-positive
bacillus Tropheryma whipplei. The classic clinical features comprise diarrhea, weight loss, …

c-Jun N-terminal kinases (JNKs) are a family of protein kinases that can be activated by
numerous stimuli and regulate a broad spectrum of biological processes in the Central Nervous …