LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent
…, DD Li Puma, A Staniszewski, H Zhang, MR Tropea… - Elife, 2017 - elifesciences.org
10.7554/eLife.26991.001 The concurrent application of subtoxic doses of soluble oligomeric
forms of human amyloid-beta (oAβ) and Tau (oTau) proteins impairs memory and its …
forms of human amyloid-beta (oAβ) and Tau (oTau) proteins impairs memory and its …
Nitric oxide/cGMP/CREB pathway and amyloid-beta crosstalk: from physiology to Alzheimer's disease
MR Tropea, W Gulisano, V Vacanti, O Arancio… - Free Radical Biology …, 2022 - Elsevier
The nitric oxide (NO)/cGMP pathway has been extensively studied for its pivotal role in
synaptic plasticity and memory processes, resulting in an increase of cAMP response element-…
synaptic plasticity and memory processes, resulting in an increase of cAMP response element-…
Neuromodulatory action of picomolar extracellular Aβ42 oligomers on presynaptic and postsynaptic mechanisms underlying synaptic function and memory
…, M Melone, C Ripoli, MR Tropea… - Journal of …, 2019 - Soc Neuroscience
Failure of anti-amyloid-β peptide (Aβ) therapies against Alzheimer's disease (AD), a
neurodegenerative disorder characterized by high amounts of the peptide in the brain, raised the …
neurodegenerative disorder characterized by high amounts of the peptide in the brain, raised the …
Amyloid-β peptide is needed for cGMP-induced long-term potentiation and memory
…, C Rebosio, E Calcagno, MR Tropea… - Journal of …, 2017 - Soc Neuroscience
High levels of amyloid-β peptide (Aβ) have been related to Alzheimer's disease pathogenesis.
However, in the healthy brain, low physiologically relevant concentrations of Aβ are …
However, in the healthy brain, low physiologically relevant concentrations of Aβ are …
[HTML][HTML] Fluoxetine and Vortioxetine Reverse Depressive-Like Phenotype and Memory Deficits Induced by Aβ1-42 Oligomers in Mice: A Key Role of Transforming …
SA Torrisi, F Geraci, MR Tropea, M Grasso… - Frontiers in …, 2019 - frontiersin.org
Depression is a risk factor for the development of Alzheimer’s disease (AD), and the
presence of depressive symptoms significantly increases the conversion of mild cognitive …
presence of depressive symptoms significantly increases the conversion of mild cognitive …
[HTML][HTML] Antioxidant activity of fluoxetine and vortioxetine in a non-transgenic animal model of alzheimer's disease
…, SA Torrisi, N Musso, F Geraci, MR Tropea… - Frontiers in …, 2021 - frontiersin.org
Depression is a risk factor for the development of Alzheimer’s disease (AD). A neurobiological
and clinical continuum exists between AD and depression, with neuroinflammation and …
and clinical continuum exists between AD and depression, with neuroinflammation and …
The effect of amyloid-β peptide on synaptic plasticity and memory is influenced by different isoforms, concentrations, and aggregation status
W Gulisano, M Melone, DDL Puma, MR Tropea… - Neurobiology of …, 2018 - Elsevier
The increase of oligomeric amyloid-beta (oAβ) has been related to synaptic dysfunction,
thought to be the earliest event in Alzheimer's disease pathophysiology. Conversely, the …
thought to be the earliest event in Alzheimer's disease pathophysiology. Conversely, the …
[HTML][HTML] Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology
MR Tropea, DDL Puma, M Melone, W Gulisano… - Progress in …, 2021 - Elsevier
The accumulation of amyloid-beta peptide (Aβ) and the failure of cholinergic transmission
are key players in Alzheimer’s disease (AD). However, in the healthy brain, Aβ contributes to …
are key players in Alzheimer’s disease (AD). However, in the healthy brain, Aβ contributes to …
[HTML][HTML] Activation of Serotonin 5-HT7 Receptors Modulates Hippocampal Synaptic Plasticity by Stimulation of Adenylate Cyclases and Rescues Learning and …
…, M Spatuzza, W Gulisano, MR Tropea… - Frontiers in molecular …, 2018 - frontiersin.org
We have previously demonstrated that activation of serotonin 5-HT 7 receptors (5-HT 7 R)
reverses metabotropic glutamate receptor-mediated long term depression (mGluR-LTD) in the …
reverses metabotropic glutamate receptor-mediated long term depression (mGluR-LTD) in the …
Salidroside, a bioactive compound of rhodiola rosea, ameliorates memory and emotional behavior in adult mice
A Palmeri, L Mammana, MR Tropea… - Journal of …, 2016 - content.iospress.com
Rhodiola Rosea (R. Rosea) is a plant used in traditional popular medicine to enhance
cognition and physical performance. R. Rosea medicinal properties have been related to its …
cognition and physical performance. R. Rosea medicinal properties have been related to its …