Tight junctions: from simple barriers to multifunctional molecular gates

C Zihni, C Mills, K Matter, MS Balda - Nature reviews Molecular cell …, 2016 - nature.com
Epithelia and endothelia separate different tissue compartments and protect multicellular
organisms from the outside world. This requires the formation of tight junctions, selective gates …

Functional dissociation of paracellular permeability and transepithelial electrical resistance and disruption of the apical-basolateral intramembrane diffusion barrier by …

MS Balda, JA Whitney, C Flores, S González… - The Journal of cell …, 1996 - rupress.org
Tight junctions, the most apical of the intercellular junctions that connect individual cells in a
epithelial sheet, are thought to form a seal that restricts paracellular and intramembrane …

Signalling to and from tight junctions

K Matter, MS Balda - Nature reviews Molecular cell biology, 2003 - nature.com
Tight junctions have long been regarded as simple barriers that separate compartments of
different compositions, but recent research indicates that different types of signalling proteins …

[HTML][HTML] The tight junction protein ZO‐1 and an interacting transcription factor regulate ErbB‐2 expression

MS Balda, K Matter - The EMBO journal, 2000 - embopress.org
Epithelial tight junctions regulate paracellular diffusion and restrict the intermixing of apical
and basolateral plasma membrane components. We now identify a Y‐box transcription factor, …

ZO-1 controls endothelial adherens junctions, cell–cell tension, angiogenesis, and barrier formation

…, AM Randi, MA Schwartz, K Matter, MS Balda - Journal of Cell …, 2015 - rupress.org
Intercellular junctions are crucial for mechanotransduction, but whether tight junctions
contribute to the regulation of cell–cell tension and adherens junctions is unknown. Here, we …

Dynamics and functions of tight junctions

E Steed, MS Balda, K Matter - Trends in cell biology, 2010 - cell.com
Tight junctions are intercellular adhesion complexes in vertebrates that are required for the
formation of functional epithelial and endothelial barriers. Their morphological appearance …

The ZO-1–associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density

MS Balda, MD Garrett, K Matter - The Journal of cell biology, 2003 - rupress.org
Epithelial tight junctions regulate paracellular permeability, restrict apical/basolateral
intramembrane diffusion of lipids, and have been proposed to participate in the control of epithelial …

Assembly of the tight junction: the role of diacylglycerol.

MS Balda, L Gonzalez-Mariscal, K Matter… - The Journal of cell …, 1993 - rupress.org
Extracellular Ca2+ triggers assembly and sealing of tight junctions (TJs) in MDCK cells.
These events are modulated by G-proteins, phospholipase C, protein kinase C (PKC), and …

Tight junctions: molecular architecture and function

S Aijaz, MS Balda, K Matter - International review of cytology, 2006 - Elsevier
Tight junctions are the most apical component of the epithelial junctional complex and are
crucial for the formation and functioning of epithelial and endothelial barriers. They regulate …

Mammalian tight junctions in the regulation of epithelial differentiation and proliferation

K Matter, S Aijaz, A Tsapara, MS Balda - Current opinion in cell biology, 2005 - Elsevier
Tight junctions are important for the permeability properties of epithelial and endothelial
barriers as they restrict diffusion along the paracellular space. Recent observations have …