User profiles for Maria Teresa Ochoa
Maria T OchoaProfessor of Dermatology, University Southern California Verified email at usc.edu Cited by 13082 |
Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response
…, H Li, L Wenzel, BH Tan, SR Krutzik, MT Ochoa… - Science, 2006 - science.org
In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial
activity against intracellular bacteria, which in murine, but not human, monocytes and …
activity against intracellular bacteria, which in murine, but not human, monocytes and …
Induction of direct antimicrobial activity through mammalian toll-like receptors
S Thoma-Uszynski, S Stenger, O Takeuchi, MT Ochoa… - Science, 2001 - science.org
The mammalian innate immune system retains fromDrosophila a family of homologous Toll-like
receptors (TLRs) that mediate responses to microbial ligands. Here, we show that TLR2 …
receptors (TLRs) that mediate responses to microbial ligands. Here, we show that TLR2 …
Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses
J Kim, MT Ochoa, SR Krutzik, O Takeuchi… - The Journal of …, 2002 - journals.aai.org
One of the factors that contributes to the pathogenesis of acne is Propionibacterium acnes;
yet, the molecular mechanism by which P. acnes induces inflammation is not known. Recent …
yet, the molecular mechanism by which P. acnes induces inflammation is not known. Recent …
TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells
Leprosy enables investigation of mechanisms by which the innate immune system contributes
to host defense against infection, because in one form, the disease progresses, and in the …
to host defense against infection, because in one form, the disease progresses, and in the …
Activation and regulation of Toll-like receptors 2 and 1 in human leprosy
SR Krutzik, MT Ochoa, PA Sieling, S Uematsu… - Nature medicine, 2003 - nature.com
The expression and activation of Toll-like receptors (TLRs) was investigated in leprosy, a
spectral disease in which clinical manifestations correlate with the type of immune response …
spectral disease in which clinical manifestations correlate with the type of immune response …
[HTML][HTML] Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells
RE Hunger, PA Sieling, MT Ochoa… - The Journal of …, 2004 - Am Soc Clin Investig
Langerhans cells (LCs) constitute a subset of DCs that initiate immune responses in skin.
Using leprosy as a model, we investigated whether expression of CD1a and langerin, an LC-…
Using leprosy as a model, we investigated whether expression of CD1a and langerin, an LC-…
Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens
A key target of many intracellular pathogens is the macrophage. Although macrophages
can generate antimicrobial activity, neutrophils have been shown to have a key role in host …
can generate antimicrobial activity, neutrophils have been shown to have a key role in host …
Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma
…, J Jalil, P de la Rocha, TA McCannel, MT Ochoa… - Clinical Cancer …, 2009 - AACR
Purpose: Tumor antigen–loaded dendritic cells (DC) are believed to activate antitumor
immunity by stimulating T cells, and CTL-associated antigen 4 (CTLA4)–blocking antibodies …
immunity by stimulating T cells, and CTL-associated antigen 4 (CTLA4)–blocking antibodies …
Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10
…, SM Kiertscher, MT Ochoa… - The Journal of …, 2000 - journals.aai.org
Mammalian Toll-like receptors (TLRs) are required for cell activation by bacterial
lipoproteins (bLP) and LPS. Stimulation of monocytes with bLP and LPS results in a TLR-dependent …
lipoproteins (bLP) and LPS. Stimulation of monocytes with bLP and LPS results in a TLR-dependent …
[PDF][PDF] Divergence of macrophage phagocytic and antimicrobial programs in leprosy
Effective innate immunity against many microbial pathogens requires macrophage programs
that upregulate phagocytosis and direct antimicrobial pathways, two functions generally …
that upregulate phagocytosis and direct antimicrobial pathways, two functions generally …