User profiles for Maria Teresa Ochoa

Maria T Ochoa

Professor of Dermatology, University Southern California
Verified email at usc.edu
Cited by 13082

Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response

…, H Li, L Wenzel, BH Tan, SR Krutzik, MT Ochoa… - Science, 2006 - science.org
In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial
activity against intracellular bacteria, which in murine, but not human, monocytes and …

Induction of direct antimicrobial activity through mammalian toll-like receptors

S Thoma-Uszynski, S Stenger, O Takeuchi, MT Ochoa… - Science, 2001 - science.org
The mammalian innate immune system retains fromDrosophila a family of homologous Toll-like
receptors (TLRs) that mediate responses to microbial ligands. Here, we show that TLR2 …

Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses

J Kim, MT Ochoa, SR Krutzik, O Takeuchi… - The Journal of …, 2002 - journals.aai.org
One of the factors that contributes to the pathogenesis of acne is Propionibacterium acnes;
yet, the molecular mechanism by which P. acnes induces inflammation is not known. Recent …

TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells

SR Krutzik, B Tan, H Li, MT Ochoa, PT Liu… - Nature medicine, 2005 - nature.com
Leprosy enables investigation of mechanisms by which the innate immune system contributes
to host defense against infection, because in one form, the disease progresses, and in the …

Activation and regulation of Toll-like receptors 2 and 1 in human leprosy

SR Krutzik, MT Ochoa, PA Sieling, S Uematsu… - Nature medicine, 2003 - nature.com
The expression and activation of Toll-like receptors (TLRs) was investigated in leprosy, a
spectral disease in which clinical manifestations correlate with the type of immune response …

[HTML][HTML] Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells

RE Hunger, PA Sieling, MT Ochoa… - The Journal of …, 2004 - Am Soc Clin Investig
Langerhans cells (LCs) constitute a subset of DCs that initiate immune responses in skin.
Using leprosy as a model, we investigated whether expression of CD1a and langerin, an LC-…

Macrophages acquire neutrophil granules for antimicrobial activity against intracellular pathogens

…, MT Ochoa, SR Krutzik, BR Bloom, T Ganz… - The Journal of …, 2006 - journals.aai.org
A key target of many intracellular pathogens is the macrophage. Although macrophages
can generate antimicrobial activity, neutrophils have been shown to have a key role in host …

Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma

…, J Jalil, P de la Rocha, TA McCannel, MT Ochoa… - Clinical Cancer …, 2009 - AACR
Purpose: Tumor antigen–loaded dendritic cells (DC) are believed to activate antitumor
immunity by stimulating T cells, and CTL-associated antigen 4 (CTLA4)–blocking antibodies …

Activation of toll-like receptor 2 on human dendritic cells triggers induction of IL-12, but not IL-10

…, SM Kiertscher, MT Ochoa… - The Journal of …, 2000 - journals.aai.org
Mammalian Toll-like receptors (TLRs) are required for cell activation by bacterial
lipoproteins (bLP) and LPS. Stimulation of monocytes with bLP and LPS results in a TLR-dependent …

[PDF][PDF] Divergence of macrophage phagocytic and antimicrobial programs in leprosy

D Montoya, D Cruz, RMB Teles, DJ Lee, MT Ochoa… - Cell host & …, 2009 - cell.com
Effective innate immunity against many microbial pathogens requires macrophage programs
that upregulate phagocytosis and direct antimicrobial pathways, two functions generally …