Emerging evidence indicates that metabolic dysregulation drives prostate cancer (PCa)
progression and metastasis. AMP-activated protein kinase (AMPK) is a master regulator of …

CD4 and CD8 mark helper and cytotoxic T cell lineages, respectively, and serve as coreceptors
for MHC-restricted TCR recognition. How coreceptor expression is matched with TCR …

Chromosome movements and programmed DNA double-strand breaks (DSBs) promote
homologue pairing and initiate recombination at meiosis onset. Meiotic progression involves …

Chromosome movements and programmed DNA double-strand breaks (DSBs) promote
homologue pairing and initiate recombination at meiosis onset. Meiotic progression involves …

The gut microbiota is a complex ecosystem that has a symbiotic relationship with its host. An
association between the gut microbiota and disease was first postulated in the early 20 th …

Cell competition is emerging as a quality control mechanism that eliminates unfit cells in a
wide range of settings from development to the adult. However, the nature of the cells …

Pre-mRNA processing is an essential mechanism for the generation of mature mRNA and
the regulation of gene expression in eukaryotic cells. While defects in pre-mRNA processing …

Background & Aims Direct-acting antiviral (DAA) therapy for HCV has high efficacy and limited
toxicity. We hypothesised that the efficacy of glecaprevir-pibrentasvir for chronic HCV with …

Endothelial cells line the blood and lymphatic vasculature, and act as an essential physical
barrier, control nutrient transport, facilitate tissue immunosurveillance and coordinate …

Drawing on historical and environmental research, this essay examines long-term trends in
the ways that mining affected labour and the environment in Latin America. The article …