The accumulation of vascular smooth muscle (SMC)-like cells and stem cell-derived myogenic
and osteogenic progeny contributes significantly to arteriosclerotic disease. This study …

Atherosclerosis is one of the leading causes of mortality worldwide, and presents as a narrowing
or occlusion of the arterial lumen. Interventions to re-open the arterial lumen can result …

A hallmark of subclinical atherosclerosis is the accumulation of vascular smooth muscle cell
(SMC)-like cells leading to intimal thickening and lesion formation. While medial SMCs …

A hallmark of subclinical atherosclerosis is the accumulation of vascular smooth muscle cell
(SMC)-like cells leading to intimal thickening. While medial SMCs contribute, the …

Dendritic cells (DCs) provide an essential link between innate and adaptive immunity. At the
site of infection, antigens recognized by DCs via pattern-recognition receptors, such as Toll-…

Notch signalling, critical for development and postnatal homeostasis of the vascular system,
is highly regulated by several mechanisms including glycosylation. While the importance of …

Cardiovascular disease is the leading cause of death worldwide, with multipotent vascular
stem cells (MVSC) implicated in contributing to diseased vessels. MVSC are …

Vascular smooth muscle cells (SMCs) are thought to display cellular plasticity by alternating
between a quiescent ‘contractile’differentiated phenotype and a proliferative ‘synthetic’de-…

Vascular remodelling leading to arterial obstruction is a hallmark of arteriosclerosis and in-stent
restenosis and is due in part to the accumulation of vascular smooth muscle (SMC)-like …

The origin (s) of smooth muscle-like cells contributing to the development of subclinical
arteriosclerosis remains controversial. Using Sca1-eGFP and S100β-eGFP transgenic mice …