The proliferation and activation of microglial cells is a hallmark of several neurodegenerative
conditions. This mechanism is regulated by the activation of the colony-stimulating factor 1 …

Amyloid β (Aβ) and tau protein are both implicated in memory impairment, mild cognitive
impairment (MCI), and early Alzheimer's disease (AD), but whether and how they interact is …

Chronic pain hypersensitivity depends on N-methyl-D-aspartate receptors (NMDARs).
However, clinical use of NMDAR blockers is limited by side effects resulting from suppression of …

Cognitive dysfunction in Alzheimer’s disease (AD) is caused by disturbances in neuronal
circuits of the brain underpinned by synapse loss, neuronal dysfunction and neuronal death. …

The NMDA receptor (NMDAR) produces a long-lasting component of the glutamatergic EPSC
in mammalian central neurons. The current through NMDARs is voltage dependent as a …

Local GABA (γ-aminobutyric acid) circuits contribute to sensory experience–dependent
refinement of neuronal connections in the developing nervous system, but whether GABAergic …

The study of neurogenesis during chronic neurodegeneration is crucial in order to understand
the intrinsic repair mechanisms of the brain, and key to designing therapeutic strategies. …

Neurofibrillary tangles, formed of misfolded, hyperphosphorylated tau protein, are a pathological
hallmark of several neurodegenerations, including Alzheimer's disease. Tau pathology …

Phagosomes employ lytic enzymes, cationic peptides, and reactive oxygen intermediates to
eliminate invading microorganisms. The effectiveness of these microbicidal mechanisms is …

RNA G-quadruplexes (G4s) are secondary structures proposed to function as regulators of
post-transcriptional mRNA localisation and translation. G4s within some neuronal mRNAs are …