Activation of the innate immune STimulator of INterferon Genes (STING) pathway potentiates
antitumour immunity, but systemic delivery of STING agonists to tumours is challenging. We …

Adoptive cell therapy (ACT) with antigen-specific T cells has shown remarkable clinical
success; however, approaches to safely and effectively augment T cell function, especially in …

Cyclic dinucleotides (CDNs) are agonists of stimulator of IFN genes (STING) and have
potential as vaccine adjuvants. However, cyclic di-GMP (cdGMP) injected sc shows minimal …

Natural infections expose the immune system to escalating antigen and inflammation over
days to weeks, whereas nonlive vaccines are single bolus events. We explored whether the …

Conventional immunization strategies will likely be insufficient for the development of a broadly
neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of the …

"Triple-defective" (3d) mice carrying a mutation in UNC93B1, a chaperone for the endosomal
nucleic acid-sensing (NAS) Toll-like receptors TLR3, TLR7, and TLR9, are highly …

Infection with the protozoan parasite Trypanosoma cruzi, the agent of Chagas disease, is
characterised by a variable clinical course – from symptomless cases to severe chronic …

The obligate intracellular parasite Toxoplasma gondii secretes effector proteins into the host
cell that manipulate the immune response allowing it to establish a chronic infection. …

To combat the HIV epidemic and emerging threats such as SARS-CoV-2, immunization
strategies are needed that elicit protection at mucosal portals of pathogen entry. Immunization …

Toxoplasma is a highly successful parasite that establishes a life-long chronic infection. To
do this, it must carefully regulate immune activation and host cell effector mechanisms. Here …