Obesity-induced insulin resistance is a major risk factor for the development of type 2 diabetes.
Basal fat cell lipolysis (ie, fat cell triacylglycerol breakdown into fatty acids and glycerol in …

When energy is needed, white adipose tissue (WAT) provides fatty acids (FAs) for use in
peripheral tissues via stimulation of fat cell lipolysis. FAs have been postulated to play a critical …

The pro-inflammatory cytokine IL-1β has been shown to promote angiogenesis. It can have
a neurotoxic or neuroprotective effect. Here, we have studied the expression of IL-1β in vivo …

Drusen, the white yellowish deposits that can be seen in funduscopy, are a hallmark of age-related
macular degeneration. Histologically, drusen are believed to be dome-shaped or …

Age-related macular degeneration (AMD) represents the major cause of vision loss in
industrialized nations. Laminar deposits in Bruch's membrane (BM) are among the first prominent …

α-Lipoic acid (α-Lip) is a natural occurring antioxidant with beneficial anti-obesity properties.
The aim of this study was to investigate the putative effects of α-Lip on mitochondrial …

Impaired adipose tissue insulin signalling is a critical feature of insulin resistance. Here we
identify a pathway linking the lipolytic enzyme hormone-sensitive lipase (HSL) to insulin …

Background In the Western world, a major cause of blindness is age-related macular
degeneration (AMD). Recent research in angiogenesis has furthered the understanding of …

Aims/hypothesis Activation of macrophages by fatty acids (FAs) is a potential mechanism
linking obesity to adipose tissue (AT) inflammation and insulin resistance. Here, we …

Early development is a critical period during which environmental influences can have a
significant impact on the health, welfare, robustness and performance of livestock. In oviparous …