Several human B cell subpopulations are recognised in the peripheral blood, which play
distinct roles in the humoral immune response. These cells undergo developmental and …

B cells play a central role in adaptive immune processes, mainly through the production of
antibodies. The maturation of the B cell system with age is poorly studied. We extensively …

The advent of next‐generation sequencing (NGS) now allows a detailed assessment of the
adaptive immune system in health and disease. In particular, high‐throughput B‐cell …

Nowadays, due to the advance of experimental techniques in glycomics, large collections of
glycan profiles are regularly published. The rapid growth of available glycan data …

Background and Objectives Autologous hematopoietic stem cell transplantation (aHSCT) is
increasingly used to treat aggressive forms of multiple sclerosis (MS). This procedure is …

Immunoglobulin loci-transgenic animals are widely used in antibody discovery and
increasingly in vaccine response modelling. In this study, we phenotypically characterised B-cell …

Background Biallelic mutations in LIG4 encoding DNA-ligase 4 cause a rare immunodeficiency
syndrome manifesting as infant-onset life-threatening and/or opportunistic infections, …

B cells play a central role in adaptive immune processes, mainly through the production of
antibodies. The maturation of the B-cell system with age is poorly studied. We extensively …

B cells play a central role in adaptive immune processes, mainly through the production of
antibodies. The maturation of the B-cell system through continuous antigen exposure with age …

T cell receptor repertoire sequencing (TCRseq) has become one of the major omic tools to
study the immune system in health and disease. Multiple commercial solutions are currently …