ALIX plays a role in nucleocapsid release during viral infection, as does lysobisphosphatidic
acid (LBPA). However, the mechanism remains unclear. Here we report that LBPA is …

Endosomes along the degradation pathway leading to lysosomes accumulate membranes
in their lumen and thus exhibit a characteristic multivesicular appearance. These lumenal …

Tubulin dimers assemble into dynamic microtubules, which are used by molecular motors as
tracks for intracellular transport. Organization and dynamics of the microtubule network are …

Microtubules, a critical component of the cytoskeleton, carry post-translational modifications
(PTMs) that are important for the regulation of key cellular processes. Long-lived …

Regulation of microtubule dynamics is essential for diverse cellular functions, and proteins
that bind to dynamic microtubule ends can regulate network dynamics. Here, we show that …

Proteins exist in one of two generally incompatible states: either membrane associated or
soluble. Pore-forming proteins are exceptional because they are synthesized as a water-…

Sensitivity of mammalian cells to the bacterial toxin aerolysin is due to the presence at their
surface of glycosylphosphatidyl inositol (GPI)-anchored proteins which act as receptors. …

The properties of single microtubules within the microtubule network can be modulated
through post-translational modifications (PTMs), including acetylation within the lumen of …

The pore-forming toxin aerolysin is secreted byAeromonas hydrophila as an inactive precursor.
Based on chemical cross-linking and gel filtration, we show here that proaerolysin exists …

N-Glycosylation affects the function of ion channels at the level of multisubunit assembly,
protein trafficking, ligand binding and channel opening. Like the majority of membrane proteins, …