Mechanism of actin-based motility
D Pantaloni, CL Clainche, MF Carlier - Science, 2001 - science.org
Spatially controlled polymerization of actin is at the origin of cell motility and is responsible
for the formation of cellular protrusions like lamellipodia. The pathogens Listeria …
for the formation of cellular protrusions like lamellipodia. The pathogens Listeria …
Regulation of actin assembly associated with protrusion and adhesion in cell migration
C Le Clainche, MF Carlier - Physiological reviews, 2008 - journals.physiology.org
To migrate, a cell first extends protrusions such as lamellipodia and filopodia, forms adhesions,
and finally retracts its tail. The actin cytoskeleton plays a major role in this process. The …
and finally retracts its tail. The actin cytoskeleton plays a major role in this process. The …
Reconstitution of actin-based motility of Listeria and Shigella using pure proteins
TP Loisel, R Boujemaa, D Pantaloni, MF Carlier - Nature, 1999 - nature.com
Actin polymerization is essential for cell locomotion and is thought to generate the force
responsible for cellular protrusions. The Arp2/3 complex is required to stimulate actin assembly …
responsible for cellular protrusions. The Arp2/3 complex is required to stimulate actin assembly …
Actin polymerization and ATP hydrolysis
ED Korn, MF Carlier, D Pantaloni - Science, 1987 - science.org
F-actin is the major component of muscle thin filaments and, more generally, of the
microfilaments of the dynamic, multifunctional cytoskeletal systems of nonmuscle eukaryotic cells. …
microfilaments of the dynamic, multifunctional cytoskeletal systems of nonmuscle eukaryotic cells. …
[HTML][HTML] Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation
…, P Bousso, F Chrétien, MF Carlier… - The Journal of …, 2013 - Am Soc Clin Investig
Mycolactone is a diffusible lipid secreted by the human pathogen Mycobacterium ulcerans,
which induces the formation of open skin lesions referred to as Buruli ulcers. Here, we show …
which induces the formation of open skin lesions referred to as Buruli ulcers. Here, we show …
Control of actin dynamics in cell motility
MF Carlier, D Pantaloni - Journal of molecular biology, 1997 - Elsevier
Actin polymerization plays a major role in cell movement. The controls of actin sequestration/desequestration
and of filament turnover are two important features of cell motility. Actin …
and of filament turnover are two important features of cell motility. Actin …
Actin depolymerizing factor (ADF/cofilin) enhances the rate of filament turnover: implication in actin-based motility
MF Carlier, V Laurent, J Santolini, R Melki… - The Journal of cell …, 1997 - rupress.org
Actin-binding proteins of the actin depolymerizing factor (ADF)/cofilin family are thought to
control actin-based motile processes. ADF1 from Arabidopsis thaliana appears to be a good …
control actin-based motile processes. ADF1 from Arabidopsis thaliana appears to be a good …
How profilin promotes actin filament assembly in the presence of thymosin β4
D Pantaloni, MF Carlier - Cell, 1993 - cell.com
The role of profilin in the regulation of actin assembly has been reexamined. The affinity of
profilin for ATP-actin appears lo-fold higher than previously thought. In the presence of ATP, …
profilin for ATP-actin appears lo-fold higher than previously thought. In the presence of ATP, …
[HTML][HTML] Flexibility of actin filaments derived from thermal fluctuations: effect of bound nucleotide, phalloidin, and muscle regulatory proteins
…, A Fattoum, R Kassab, D Pantaloni, MF Carlier - Journal of Biological …, 1995 - ASBMB
Single actin filaments undergoing brownian movement in two dimensions were observed at
20 C in fluorescence optical video microscopy. The persistence length (L p ) was derived …
20 C in fluorescence optical video microscopy. The persistence length (L p ) was derived …
[HTML][HTML] Formin is a processive motor that requires profilin to accelerate actin assembly and associated ATP hydrolysis
…, D Didry, C Egile, D Pantaloni, MF Carlier - Cell, 2004 - cell.com
Motile and morphogenetic cellular processes are driven by site-directed assembly of actin
filaments. Formins, proteins characterized by formin homology domains FH1 and FH2, are …
filaments. Formins, proteins characterized by formin homology domains FH1 and FH2, are …