Recent genome-wide association studies have described many loci implicated in type 2
diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the …

The convergence of advances in medical science, human biology, data science, and
technology has enabled the generation of new insights into the phenotype known as “diabetes.” …

Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …

Patients with established type 2 diabetes display both β-cell dysfunction and insulin
resistance. To define fundamental processes leading to the diabetic state, we examined the …

Context: Adipose tissue-derived adipokines may contribute to insulin resistance. Objective:
We tested the hypothesis that adipokines are associated with insulin resistance in a …

Epidemiological evidence is accumulating that indicates greater time spent in sedentary
behavior is associated with all-cause and cardiovascular morbidity and mortality in adults such …

Noncommunicable diseases (NCDs) have become the primary health concern for most
countries around the world. Currently, more than 36 million people worldwide die from NCDs …

Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …

Glucose levels 2 h after an oral glucose challenge are a clinical measure of glucose tolerance
used in the diagnosis of type 2 diabetes. We report a meta-analysis of nine genome-wide …

Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are
highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other …