The stretch-induced increase in force production of ventricular muscle is biphasic. An abrupt
increase in force coincides with the stretch, which is then followed by a slower response that …

Cardiac dysfunction is a well-known consequence of diabetes, with sustained hyperglycaemia
leading to the development of a cardiomyopathy that is independent of cardiovascular …

OBJECTIVE—This study examines the extent to which the contractile deficit of diabetic
cardiomyopathy is due to altered Ca 2+ homeostasis. RESEARCH DESIGN AND METHODS—…

Background Intracellular calcium (Ca 2+ ) coordinates the cardiac contraction cycle and is
dysregulated in diabetic cardiomyopathy. Treatment with triethylenetetramine (TETA), a …

Intracellular calcium ([Ca 2+ ] i ) and isometric force were measured in left ventricular (LV)
trabeculae from spontaneously hypertensive rats (SHR) with failing hearts and normotensive …

The heat liberated upon stress production in isolated cardiac muscle provides insights into
the complex thermodynamic processes underlying mechanical contraction. To that end, we …

Background A transient increase in cytosolic Ca 2+ (the “Ca 2+ transient”) determines the
degree and duration of myocyte force development in the heart. However, we have previously …

Pulmonary hypertension (PH) increases the work of the right ventricle (RV) and causes right-sided
heart failure. This study examined RV mitochondrial function and ADP transfer in PH …

When exposed to an abrupt stretch, cardiac muscle exhibits biphasic active force
enhancement. The initial, instantaneous, force enhancement is well explained by the Frank‐Starling …

Background Cardiomyocyte contraction requires a constant supply of ATP, which varies
depending on work rate. Maintaining ATP supply is particularly important during excitation-…