User profiles for Marie-Ming Aynaud
 | Marie-Ming AynaudLunenfeld Tanenbaum Institute - Mount Sinai Verified email at lunenfeld.ca Cited by 1605 |
[HTML][HTML] MYBL2 (B-Myb): a central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesis
Limitless cell proliferation, evasion from apoptosis, dedifferentiation, metastatic spread and
therapy resistance: all these properties of a cancer cell contribute to its malignant phenotype …
therapy resistance: all these properties of a cancer cell contribute to its malignant phenotype …
[HTML][HTML] Massive APOBEC3 editing of hepatitis B viral DNA in cirrhosis
…, M Henry, A Marchio, R Suspène, MM Aynaud… - PLoS …, 2010 - journals.plos.org
DNA viruses, retroviruses and hepadnaviruses, such as hepatitis B virus (HBV), are
vulnerable to genetic editing of single stranded DNA by host cell APOBEC3 (A3) cytidine …
vulnerable to genetic editing of single stranded DNA by host cell APOBEC3 (A3) cytidine …
Chimeric EWSR1-FLI1 regulates the Ewing sarcoma susceptibility gene EGR2 via a GGAA microsatellite
Deciphering the ways in which somatic mutations and germline susceptibility variants cooperate
to promote cancer is challenging. Ewing sarcoma is characterized by fusions between …
to promote cancer is challenging. Ewing sarcoma is characterized by fusions between …
Somatic hypermutation of human mitochondrial and nuclear DNA by APOBEC3 cytidine deaminases, a pathway for DNA catabolism
R Suspène, MM Aynaud, D Guétard… - Proceedings of the …, 2011 - National Acad Sciences
The human APOBEC3 (A3A–A3H) locus encodes six cytidine deaminases that edit single-stranded
DNA, the result being DNA peppered with uridine. Although several cytidine …
DNA, the result being DNA peppered with uridine. Although several cytidine …
Genetic Editing of Herpes Simplex Virus 1 and Epstein-Barr Herpesvirus Genomes by Human APOBEC3 Cytidine Deaminases in Culture and In Vivo
R Suspene, MM Aynaud, S Koch, D Pasdeloup… - Journal of …, 2011 - Am Soc Microbiol
Human APOBEC3 cytidine deaminases target and edit single-stranded DNA, which can be
of viral, mitochondrial, or nuclear origin. Retrovirus genomes, such as human …
of viral, mitochondrial, or nuclear origin. Retrovirus genomes, such as human …
[PDF][PDF] Transcriptional programs define intratumoral heterogeneity of Ewing sarcoma at single-cell resolution
EWSR1-FLI1, the chimeric oncogene specific for Ewing sarcoma (EwS), induces a cascade
of signaling events leading to cell transformation. However, it remains elusive how …
of signaling events leading to cell transformation. However, it remains elusive how …
[HTML][HTML] Human APOBEC3A isoforms translocate to the nucleus and induce DNA double strand breaks leading to cell stress and death
B Mussil, R Suspène, MM Aynaud, A Gauvrit… - PloS one, 2013 - journals.plos.org
Human APOBEC3 enzymes deaminate single stranded DNA. At least five can deaminate
mitochondrial DNA in the cytoplasm, while three can deaminate viral DNA in the nucleus. …
mitochondrial DNA in the cytoplasm, while three can deaminate viral DNA in the nucleus. …
[HTML][HTML] Human Tribbles 3 protects nuclear DNA from cytidine deamination by APOBEC3A
MM Aynaud, R Suspène, PO Vidalain, B Mussil… - Journal of Biological …, 2012 - ASBMB
The human polydeoxynucleotide cytidine deaminases APOBEC3A, APOBEC3C, and
APOBEC3H are capable of mutating viral DNA in the nucleus, whereas APOBEC3A alone …
APOBEC3H are capable of mutating viral DNA in the nucleus, whereas APOBEC3A alone …
[HTML][HTML] A multiplexed, next generation sequencing platform for high-throughput detection of SARS-CoV-2
Population scale sweeps of viral pathogens, such as SARS-CoV-2, require high intensity
testing for effective management. Here, we describe “Systematic Parallel Analysis of RNA …
testing for effective management. Here, we describe “Systematic Parallel Analysis of RNA …
[HTML][HTML] Cooperation of cancer drivers with regulatory germline variants shapes clinical outcomes
Pediatric malignancies including Ewing sarcoma (EwS) feature a paucity of somatic alterations
except for pathognomonic driver-mutations that cannot explain overt variations in clinical …
except for pathognomonic driver-mutations that cannot explain overt variations in clinical …