Krüppel-like factors (KLFs) are a family of DNA-binding transcriptional regulators with
diverse and essential functions in a multitude of cellular processes, including proliferation, …

BACKGROUND & AIMS: Esophageal squamous cell cancer accounts for more than 90% of
cases of esophageal cancers. Its pathogenesis involves chronic epithelial irritation, although …

Esophageal cancer is the eighth leading cause of cancer and the sixth most common cause
of cancer-related death worldwide. Despite recent advances in the development of surgical …

Esophageal squamous cell carcinoma (ESCC) is among the most deadly forms of human
malignancy characterized by late stage diagnosis, metastasis, therapy resistance and frequent …

Esophageal cells overexpressing epidermal growth factor receptor (EGFR) and TP53
mutation can invade into the extracellular matrix when grown in 3D-organotypic cultures (OTC) …

Achalasia is an esophageal motility disorder characterized by the functional loss of
myenteric plexus ganglion cells in the distal esophagus and lower esophageal sphincter. …

Aging is among the most important risk factors for morbidity and mortality. To contribute toward
a molecular understanding of aging, we analyzed age-resolved transcriptomic data from …

Although morphologic progression coupled with expression of specific molecular markers
has been characterized along the esophageal squamous differentiation gradient, the …

BACKGROUND & AIMS: Krüppel-like factor 4 (Klf; previously known a gut-enriched Krüppel-like
factor) is a DNA-binding transcriptional regulator highly expressed in skin and …

Eosinophilic esophagitis (EoE) is an esophageal immune-mediated disease characterized
by eosinophilic inflammation and epithelial remodeling, including basal cell hyperplasia (BCH…