ATR checkpoint signaling is crucial for cellular responses to DNA replication impediments.
Using an optogenetic platform, we show that TopBP1, the main activator of ATR, self-…

Neurotrophins have multiple functions during peripheral nervous system development such
as controlling neuronal survival, target innervation and synaptogenesis. Neurotrophin …

The HER2 transmembrane receptor is a well-characterised predictive marker for trastuzumab
benefit and may be associated with decreased benefit from endocrine therapy use. …

Long non-coding RNA (lncRNA), which are sequences of more than 200 nucleotides without
a defined reading frame, belong to the regulatory non-coding RNA's family. Although their …

Botulinum neurotoxin type B (BoNT/B) recognizes nerve terminals by binding to 2 receptor
components: a polysialoganglioside, predominantly GT1b, and synaptotagmin 1/2. It is widely …

10.7554/eLife.14837.001 Paraspeckles are nuclear bodies form around the long non-coding
RNA, Neat1, and RNA-binding proteins. While their role is not fully understood, they are …

The daily temporal organization of rhythmic functions in mammals, which requires synchronization
of the circadian clock to the 24‐h light–dark cycle, is believed to involve adjustments …

Rhythmic biological functions in mammals are orchestrated by a circadian timekeeper in the
suprachiasmatic nucleus of the hypothalamus (SCN) which precisely adjusts clock outputs …

The aim of this study was to investigate whether an altered gravitational environment affected
the phenotype of vestibular hair cells during in vitro maturation. We developed, using an …

In Paramecium tetraurelia, polyamine-triggered exocytosis is accompanied by the activation
of Ca 2+ -activated currents across the cell membrane (Erxleben, C., and H. Plattner. 1994. J…