Defective cholesterol clearance limits remyelination in the aged central nervous system

…, D Fitzner, M Bosch-Queralt, MT Weil… - Science, 2018 - science.org
Age-associated decline in regeneration capacity limits the restoration of nervous system
functionality after injury. In a model for demyelination, we found that old mice fail to resolve the …

[PDF][PDF] Cell-type-and brain-region-resolved mouse brain lipidome

…, JM Bader, H Penkert, CG Bergner, M Su, MT Weil… - Cell Reports, 2020 - cell.com
Gene and protein expression data provide useful resources for understanding brain function,
but little is known about the lipid composition of the brain. Here, we perform quantitative …

[HTML][HTML] Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork

…, M Zweckstetter, A Janshoff, A Schneider, MT Weil… - PLoS …, 2013 - journals.plos.org
Rapid conduction of nerve impulses requires coating of axons by myelin. To function as an
electrical insulator, myelin is generated as a tightly packed, lipid-rich multilayered membrane …

[PDF][PDF] Loss of myelin basic protein function triggers myelin breakdown in models of demyelinating diseases

MT Weil, W Möbius, A Winkler, T Ruhwedel, C Wrzos… - Cell reports, 2016 - cell.com
Breakdown of myelin sheaths is a pathological hallmark of several autoimmune diseases of
the nervous system. We employed autoantibody-mediated animal models of demyelinating …

[PDF][PDF] Saltatory conduction along myelinated axons involves a periaxonal nanocircuit

CCH Cohen, MA Popovic, J Klooster, MT Weil… - Cell, 2020 - cell.com
The propagation of electrical impulses along axons is highly accelerated by the myelin sheath
and produces saltating or "jumping" action potentials across internodes, from one node of …

[HTML][HTML] Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model

E Romanelli, D Merkler, A Mezydlo, MT Weil… - Nature …, 2016 - nature.com
Oligodendrocyte damage is a central event in the pathogenesis of the common
neuroinflammatory condition, multiple sclerosis (MS). Where and how oligodendrocyte damage is …

[HTML][HTML] Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates

…, M Tatli, R Kolla, S Nazarov, MT Weil… - Nature …, 2023 - nature.com
Tau protein fibrillization is implicated in the pathogenesis of several neurodegenerative
diseases collectively known as Tauopathies. For decades, investigating Tau fibrillization in vitro …

[HTML][HTML] White matter integrity in mice requires continuous myelin synthesis at the inner tongue

M Meschkat, AM Steyer, MT Weil, K Kusch… - Nature …, 2022 - nature.com
Myelin, the electrically insulating sheath on axons, undergoes dynamic changes over time.
However, it is composed of proteins with long lifetimes. This raises the question how such a …

Axonal ensheathment in the nervous system of lamprey: implications for the evolution of myelinating glia

MT Weil, S Heibeck, M Töpperwien… - Journal of …, 2018 - Soc Neuroscience
In the nervous system, myelination of axons enables rapid impulse conduction and is a
specialized function of glial cells. Myelinating glia are the last cell type to emerge in the evolution …

[HTML][HTML] Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS

…, S Timmler, M Arends, M Luckner, MT Weil… - Nature …, 2019 - nature.com
Central nervous system myelin is a multilayered membrane produced by oligodendrocytes
to increase neural processing speed and efficiency, but the molecular mechanisms …