Defective cholesterol clearance limits remyelination in the aged central nervous system
…, D Fitzner, M Bosch-Queralt, MT Weil… - Science, 2018 - science.org
Age-associated decline in regeneration capacity limits the restoration of nervous system
functionality after injury. In a model for demyelination, we found that old mice fail to resolve the …
functionality after injury. In a model for demyelination, we found that old mice fail to resolve the …
[PDF][PDF] Cell-type-and brain-region-resolved mouse brain lipidome
…, JM Bader, H Penkert, CG Bergner, M Su, MT Weil… - Cell Reports, 2020 - cell.com
Gene and protein expression data provide useful resources for understanding brain function,
but little is known about the lipid composition of the brain. Here, we perform quantitative …
but little is known about the lipid composition of the brain. Here, we perform quantitative …
[HTML][HTML] Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork
Rapid conduction of nerve impulses requires coating of axons by myelin. To function as an
electrical insulator, myelin is generated as a tightly packed, lipid-rich multilayered membrane …
electrical insulator, myelin is generated as a tightly packed, lipid-rich multilayered membrane …
[PDF][PDF] Loss of myelin basic protein function triggers myelin breakdown in models of demyelinating diseases
MT Weil, W Möbius, A Winkler, T Ruhwedel, C Wrzos… - Cell reports, 2016 - cell.com
Breakdown of myelin sheaths is a pathological hallmark of several autoimmune diseases of
the nervous system. We employed autoantibody-mediated animal models of demyelinating …
the nervous system. We employed autoantibody-mediated animal models of demyelinating …
[PDF][PDF] Saltatory conduction along myelinated axons involves a periaxonal nanocircuit
CCH Cohen, MA Popovic, J Klooster, MT Weil… - Cell, 2020 - cell.com
The propagation of electrical impulses along axons is highly accelerated by the myelin sheath
and produces saltating or "jumping" action potentials across internodes, from one node of …
and produces saltating or "jumping" action potentials across internodes, from one node of …
[HTML][HTML] Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model
E Romanelli, D Merkler, A Mezydlo, MT Weil… - Nature …, 2016 - nature.com
Oligodendrocyte damage is a central event in the pathogenesis of the common
neuroinflammatory condition, multiple sclerosis (MS). Where and how oligodendrocyte damage is …
neuroinflammatory condition, multiple sclerosis (MS). Where and how oligodendrocyte damage is …
[HTML][HTML] Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates
Tau protein fibrillization is implicated in the pathogenesis of several neurodegenerative
diseases collectively known as Tauopathies. For decades, investigating Tau fibrillization in vitro …
diseases collectively known as Tauopathies. For decades, investigating Tau fibrillization in vitro …
[HTML][HTML] White matter integrity in mice requires continuous myelin synthesis at the inner tongue
M Meschkat, AM Steyer, MT Weil, K Kusch… - Nature …, 2022 - nature.com
Myelin, the electrically insulating sheath on axons, undergoes dynamic changes over time.
However, it is composed of proteins with long lifetimes. This raises the question how such a …
However, it is composed of proteins with long lifetimes. This raises the question how such a …
Axonal ensheathment in the nervous system of lamprey: implications for the evolution of myelinating glia
MT Weil, S Heibeck, M Töpperwien… - Journal of …, 2018 - Soc Neuroscience
In the nervous system, myelination of axons enables rapid impulse conduction and is a
specialized function of glial cells. Myelinating glia are the last cell type to emerge in the evolution …
specialized function of glial cells. Myelinating glia are the last cell type to emerge in the evolution …
[HTML][HTML] Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS
…, S Timmler, M Arends, M Luckner, MT Weil… - Nature …, 2019 - nature.com
Central nervous system myelin is a multilayered membrane produced by oligodendrocytes
to increase neural processing speed and efficiency, but the molecular mechanisms …
to increase neural processing speed and efficiency, but the molecular mechanisms …