Ecsit is a cytosolic adaptor protein essential for inflammatory response and embryonic
development via the Toll-like and BMP (bone morphogenetic protein) signal transduction …

Acyl-CoA dehydrogenase 9 (ACAD9) is a recently identified member of the acyl-CoA
dehydrogenase family. It closely resembles very long-chain acyl-CoA dehydrogenase (VLCAD), …

Mitochondrial complex I deficiency is the most prevalent and least understood disorder of the
oxidative phosphorylation system. The genetic cause of many cases of isolated complex I …

Mitochondrial oxidative phosphorylation (OXPHOS) is responsible for generating the majority
of cellular ATP. Complex III (ubiquinol-cytochrome c oxidoreductase) is the third of five …

Mitochondrial complex I (CI) is a multi-subunit enzyme that forms the major entry point of
nicotinamide adenine dinucleotide (NADH) electrons into the respiratory chain. Mutations in the …

Background Orthology is a central tenet of comparative genomics and ortholog identification
is instrumental to protein function prediction. Major advances have been made to determine …

… van den Heuvel, A mutation in the FAM36A gene, the human ortholog of COX20, impairs
cytochrome c oxidase assembly and is associated with ataxia and muscle hypotonia, Human …

The assembly of mitochondrial respiratory chain complex IV (cytochrome c oxidase) involves
the coordinated action of several assembly chaperones. In Saccharomyces cerevisiae, at …

Complex III (cytochrome bc 1 ) is a protein complex of the mitochondrial inner membrane
that transfers electrons from ubiquinol to cytochrome c. Its assembly requires the coordinated …

Biogenesis of the mitochondrial oxidative phosphorylation system, which produces the bulk
of ATP for almost all eukaryotic cells, depends on the translation of 13 mtDNA-encoded …