Telomere dysfunction activates p53-mediated cellular growth arrest, senescence and apoptosis
to drive progressive atrophy and functional decline in high-turnover tissues. The broader …

An ageing world population has fuelled interest in regenerative remedies that may stem
declining organ function and maintain fitness. Unanswered is whether elimination of intrinsic …

Defects in epigenetic regulation play a fundamental role in the development of cancer, and
epigenetic regulators have recently emerged as promising therapeutic candidates. We …

To assess telomerase as a cancer therapeutic target and determine adaptive mechanisms
to telomerase inhibition, we modeled telomerase reactivation and subsequent extinction in T …

To determine the role of telomere dysfunction and telomerase reactivation in generating pro-oncogenic
genomic events and in carcinoma progression, an inducible telomerase reverse …

In eukaryotic cells, the repair of DNA double-strand breaks by homologous recombination
requires a RecA-like recombinase, Rad51p, and a Swi2p/Snf2p-like ATPase, Rad54p. Here …

Clinical and genomic evidence suggests that the metastatic potential of a primary tumor may
be dictated by prometastatic events that have additional oncogenic capability. To test this "…

SWI-SNF is an ATP-dependent chromatin remodeling complex that disrupts DNA-histone
interactions. Several studies of SWI-SNF activity on mononucleosome substrates have …

Purpose: Targeting RAF for antitumor therapy in RAS-mutant tumors holds promise. Herein,
we describe in detail novel properties of the type II RAF inhibitor, LXH254. Experimental …

Chromatin architecture is modulated by a large number of enzymes, resulting in the proper
regulation of transcription, replication, cell cycle progression, DNA repair, recombination and …