Gene expression in human tissue has primarily been studied on the transcriptional level,
largely neglecting translational regulation. Here, we analyze the translatomes of 80 human …

Primary aldosteronism, a common cause of severe hypertension 1 , features constitutive
production of the adrenal steroid aldosterone. We analyzed a multiplex family with familial …

Mutations in the gene encoding the RNA-binding protein RBM20 have been implicated in
dilated cardiomyopathy (DCM), a major cause of chronic heart failure, presumably through …

All species continuously evolve short open reading frames (sORFs) that can be templated for
protein synthesis and may provide raw materials for evolutionary adaptation. We analyzed …

Background Recent studies demonstrated that the triple combination cystic fibrosis transmembrane
conductance regulator (CFTR) modulator therapy elexacaftor/tezacaftor/ivacaftor (ETI…

Sensitization of the capsaicin receptor TRPV1 is central to the initiation of pathological
forms of pain, and multiple signaling cascades are known to enhance TRPV1 activity under …

Cells adopt highly polarized shapes and form distinct subcellular compartments in many
cases due to the localization of many mRNAs to specific areas, where they are translated into …

Many disease-causing missense mutations affect intrinsically disordered regions (IDRs) of
proteins, but the molecular mechanism of their pathogenicity is enigmatic. Here, we employ a …

Spatiotemporal control of gene expression is crucial for development and subject to
evolutionary changes. Although proteins are the final product of most genes, the developmental …

Neisseria gonorrhoeae is a gram-negative bacterial pathogen which infects the human
mucosal epithelium. An early critical event in neisserial infection is the type IV pilus-mediated …