We identified rare coding variants associated with Alzheimer's disease in a three-stage case–control
study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-…

Previous genome-wide association studies (GWAS), conducted by our group and others,
have identified loci that harbor risk variants for neurodegenerative diseases, including …

We present a consensus atlas of the human brain transcriptome in Alzheimer's disease (AD),
based on meta-analysis of differential gene expression in 2,114 postmortem samples. We …

Genetic variants that modify brain gene expression may also influence risk for human
diseases. We measured expression levels of 24,526 transcripts in brain samples from the …

Objective: Recent genome-wide association studies (GWAS) of late-onset Alzheimer disease
(LOAD) identified 9 novel risk loci. Discovery of functional variants within genes at these …

Introduction MAPT encodes for tau, the predominant component of neurofibrillary tangles
that are neuropathological hallmarks of Alzheimer’s disease (AD). Genetic association of …

Introduction Comparative transcriptome analyses in Alzheimer's disease (AD) and other
neurodegenerative proteinopathies can uncover both shared and distinct disease pathways. …

We tested association of nine late-onset Alzheimer’s disease (LOAD) risk variants from
genome-wide association studies (GWAS) with memory and progression to mild cognitive …

Selective vulnerability of different brain regions is seen in many neurodegenerative
disorders. The hippocampus and cortex are selectively vulnerable in Alzheimer’s disease (AD), …

The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously
associated with a reduced Alzheimer’s disease risk (AD). The role of PLCG2 in immune system …