Effector functions of immunoglobulin G (IgG) are regulated by the composition of a glycan
moiety, thus affecting activity of the immune system. Aberrant glycosylation of IgG has been …

Background Type 2 diabetes results from interplay between genetic and acquired factors.
Glycans on proteins reflect genetic, metabolic and environmental factors. However, …

Background & Aims Biomarkers are needed for early detection of Crohn’s disease (CD) and
ulcerative colitis (UC) or to predict patient outcomes. Glycosylation is a common and …

Immunoglobulin G (IgG) glycosylation is essential for function of the immune system, but the
genetic and environmental factors that underlie its inter-individual variability are not well …

Post-translational modifications diversify protein functions and dynamically coordinate their
signalling networks, influencing most aspects of cell physiology. Nevertheless, their genetic …

Human plasma transferrin (Tf) N-glycosylation has been mostly studied as a marker for
congenital disorders of glycosylation, alcohol abuse, and hepatocellular carcinoma. However, …

Glycosylation is a common post-translational modification of proteins. Glycosylation is
associated with a number of human diseases. Defining genetic factors altering glycosylation may …

Immunoglobulin G (IgG) is the most abundant serum antibody which structural characteristics
and effector functions are modulated through the attachment of various sugar moieties …

Immunoglobulin G (IgG) is a major effector molecule of the human immune response, and
aberrations in IgG glycosylation are linked to various diseases. However, the molecular …

Glycoproteins, proteins that are co- and posttranslationally modified by sugars (glycans),
have significant roles in pathophysiology of many different diseases. One of the main steps in …