[HTML][HTML] Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individuals
M Jaago, A Rähni, N Pupina, A Pihlak, H Sadam… - Scientific Reports, 2022 - nature.com
Immunity to previously encountered viruses can alter response to unrelated pathogens. We
reasoned that similar mechanism may also involve SARS-CoV-2 and thereby affect the …
reasoned that similar mechanism may also involve SARS-CoV-2 and thereby affect the …
[HTML][HTML] Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients
H Sadam, A Pihlak, M Jaago, N Pupina, A Rähni… - …, 2021 - thelancet.com
Background Optic neuritis (ON) can occur as an isolated episode or will develop to multiple
sclerosis (MS) a chronic autoimmune disease. What predicts ON progression to MS remains …
sclerosis (MS) a chronic autoimmune disease. What predicts ON progression to MS remains …
[HTML][HTML] Prostaglandin D2 receptor DP1 antibodies predict vaccine-induced and spontaneous narcolepsy type 1: large-scale study of antibody profiling
H Sadam, A Pihlak, A Kivil, S Pihelgas, M Jaago… - …, 2018 - thelancet.com
Background Neuropathological findings support an autoimmune etiology as an underlying
factor for loss of orexin-producing neurons in spontaneous narcolepsy type 1 (narcolepsy …
factor for loss of orexin-producing neurons in spontaneous narcolepsy type 1 (narcolepsy …
[HTML][HTML] Antibody response to oral biofilm is a biomarker for acute coronary syndrome in periodontal disease
M Jaago, N Pupina, A Rähni, A Pihlak… - Communications …, 2022 - nature.com
Cumulative evidence over the last decades have supported the role of gum infections as a
risk for future major cardiovascular events. The precise mechanism connecting coronary …
risk for future major cardiovascular events. The precise mechanism connecting coronary …
Daughterless, the Drosophila orthologue of TCF4, is required for associative learning and maintenance of the synaptic proteome
L Tamberg, M Jaago, K Säälik, A Sirp… - Disease models & …, 2020 - journals.biologists.com
Mammalian transcription factor 4 (TCF4) has been linked to schizophrenia and intellectual
disabilities, such as Pitt – Hopkins syndrome (PTHS). Here, we show that similarly to …
disabilities, such as Pitt – Hopkins syndrome (PTHS). Here, we show that similarly to …
[HTML][HTML] Drastic Effects on the Microbiome of a Young Rower Engaged in High-Endurance Exercise After a Month Usage of a Dietary Fiber Supplement
M Jaago, US Timmusk, T Timmusk, K Palm - Frontiers in nutrition, 2021 - frontiersin.org
Food supplements are increasingly used worldwide. However, research on the efficacy of
such supplements on athlete's well-being and optimal sports performance is very limited. This …
such supplements on athlete's well-being and optimal sports performance is very limited. This …
[HTML][HTML] Immune response to a conserved enteroviral epitope of the major capsid VP1 protein is associated with lower risk of cardiovascular disease
N Pupina, A Avarlaid, H Sadam, A Pihlak, M Jaago… - …, 2022 - thelancet.com
Background Major cardiac events including myocardial infarction (MI) are associated with
viral infections. However, how specific infections contribute to the cardiovascular insults has …
viral infections. However, how specific infections contribute to the cardiovascular insults has …
[HTML][HTML] Melanoma-specific antigen-associated antitumor antibody reactivity as an immune-related biomarker for targeted immunotherapies
A Rähni, M Jaago, H Sadam, N Pupina… - Communications …, 2022 - nature.com
Background: Immunotherapies, including cancer vaccines and immune checkpoint inhibitors
have transformed the management of many cancers. However, a large number of patients …
have transformed the management of many cancers. However, a large number of patients …
High seroreactivity against SARS-CoV-2 Spike epitopes in a pre SARS-CoV-2 cohort: implications for antibody testing and vaccine design
K Palm, M Jaago, A Rähni, N Pupina, A Pihlak… - medRxiv, 2020 - medrxiv.org
Little is known about the quality of polyclonal antibody responses in COVID-19 patients, and
how it correlates with disease severity or patients’ prior exposure to other pathogens. The …
how it correlates with disease severity or patients’ prior exposure to other pathogens. The …
Melanoma-specific antigen-associated antitumor antibody reactivity as an immune-related biomarker for targeted immunotherapies
M Jaago, H Sadam, A Pihlak… - Communications … - nottingham-repository.worktribe.com
Background: Immunotherapies, including cancer vaccines and immune checkpoint inhibitors
have transformed the management of many cancers. However, a large number of patients …
have transformed the management of many cancers. However, a large number of patients …