[HTML][HTML] Standards and guidelines for the interpretation and reporting of sequence variants in cancer: a joint consensus recommendation of the Association for …
Widespread clinical laboratory implementation of next-generation sequencing–based
cancer testing has highlighted the importance and potential benefits of standardizing the …
cancer testing has highlighted the importance and potential benefits of standardizing the …
[PDF][PDF] Integrated proteogenomic characterization across major histological types of pediatric brain cancer
We report a comprehensive proteogenomics analysis, including whole-genome sequencing,
RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 …
RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 …
[PDF][PDF] Integrated molecular and clinical analysis of 1,000 pediatric low-grade gliomas
Pediatric low-grade gliomas (pLGG) are frequently driven by genetic alterations in the RAS-mitogen-activated
protein kinase (RAS/MAPK) pathway yet show unexplained variability in …
protein kinase (RAS/MAPK) pathway yet show unexplained variability in …
[HTML][HTML] Application of next generation sequencing in laboratory medicine
The rapid development of next-generation sequencing (NGS) technology, including advances
in sequencing chemistry, sequencing technologies, bioinformatics, and data interpretation…
in sequencing chemistry, sequencing technologies, bioinformatics, and data interpretation…
AACR Project GENIE: 100,000 cases and beyond
AACR Project GENIE has now accrued data from >110,000 tumors, placing it among the
largest repository of publicly available, clinically annotated genomic data in the world. GENIE …
largest repository of publicly available, clinically annotated genomic data in the world. GENIE …
Clinical application of amplicon-based next-generation sequencing in cancer
F Chang, MM Li - Cancer genetics, 2013 - Elsevier
Next-generation sequencing (NGS) technology has revolutionized genomic research by
decreasing the cost of sequencing while increasing the throughput. The focus now is on …
decreasing the cost of sequencing while increasing the throughput. The focus now is on …
[HTML][HTML] Fusion oncogenes are associated with increased metastatic capacity and persistent disease in pediatric thyroid cancers
…, L Surrey, TW Laetsch, MM Li… - Journal of Clinical …, 2022 - ncbi.nlm.nih.gov
PURPOSE In 2014, data from a comprehensive multiplatform analysis of 496 adult papillary
thyroid cancer samples reported by The Cancer Genome Atlas project suggested that …
thyroid cancer samples reported by The Cancer Genome Atlas project suggested that …
[HTML][HTML] Clinical utility of custom-designed NGS panel testing in pediatric tumors
Background Somatic genetic testing is rapidly becoming the standard of care in many adult
and pediatric cancers. Previously, the standard approach was single-gene or focused …
and pediatric cancers. Previously, the standard approach was single-gene or focused …
[HTML][HTML] Points to consider for reporting of germline variation in patients undergoing tumor testing: a statement of the American College of Medical Genetics and …
The sequencing of tumor-derived DNA to identify tumor-specific variations (biomarkers) with
potential diagnostic, prognostic, or predictive therapeutic implications (hereafter,“tumor …
potential diagnostic, prognostic, or predictive therapeutic implications (hereafter,“tumor …
High incidence of Philadelphia chromosome-like acute lymphoblastic leukemia in older adults with B-ALL
Treatment of patients with Philadelphia chromosome-positive B-cell acute lymphoblastic
leukemia (Ph+ B-ALL) with tyrosine kinase inhibitors (TKIs) such as imatinib and dasatinib has …
leukemia (Ph+ B-ALL) with tyrosine kinase inhibitors (TKIs) such as imatinib and dasatinib has …