Human accelerated regions (HARs) are conserved genomic loci that evolved at an accelerated
rate in the human lineage and may underlie human-specific traits. We generated HARs …

Nucleotide changes in gene regulatory elements are important determinants of neuronal
development and disease. Using massively parallel reporter assays in primary human cells …

Cas9 targets genomic loci with high specificity. For knockin with double-strand break repair,
however, Cas9 often leads to unintended on-target knockout rather than intended edits. This …

Primary sensory neurons are generally considered the only source of dorsal horn calcitonin
gene-related peptide (CGRP), a neuropeptide critical to the transmission of pain messages. …

The developing human cerebellum has a greater diversity of progenitor types than that of
the mouse, necessitating a human-based model for studying cerebellar development and …

Throughout developmental biology, and indeed biology as a whole, structure and function
are intimately linked. This relationship is elegantly exemplified by neural stem cells of the …

Current Cas9 reagents can target genomic loci with high specificity. However, when used for
knockin, on-target outcomes are inherently imprecise, often leading to unintended knockout …

Generating animal models for individual patients within clinically relevant time frames holds
the potential to revolutionize personalized medicine for rare genetic epilepsies. By …

An important involvement of the Wnt protein family in the pathophysiology of spinal cord
injury (SCI) has been recently demonstrated, participating in the regulation of different …

… Steyert … Steyert, 2022. All rights reserved. … Susan Leonard and my sister Marilyn
Steyert for helping me grow up to be the person I am today. My mom taught me to …