Microtubules are hollow biopolymers of 25-nm diameter and are key constituents of the
cytoskeleton. In neurons, microtubules are organized differently between axons and dendrites, …

In neurons, the distinct molecular composition of axons and dendrites is established through
polarized targeting mechanisms, but it is currently unclear how nonpolarized cargoes, such …

Several studies indicate that NMDA receptor signaling is involved in Aβ oligomer-mediated
impairment of neuronal function and morphology. Utilizing primary neuronal cell culture and …

The prion protein (PrP C ) is a central player in neurodegenerative diseases, such as prion
diseases or Alzheimer’s disease. In contrast to disease-promoting cell surface PrP C , …

In neurons, most microtubules are not associated with a central microtubule-organizing
center (MTOC), and therefore, both the minus and plus-ends of these noncentrosomal …

The activation of N-methyl-D-aspartate-receptors (NMDARs) in synapses provides plasticity
and cell survival signals, whereas NMDARs residing in the neuronal membrane outside …

Expression of synaptic plasticity involves the translation of mRNA into protein and, probably,
active protein degradation via the proteasome pathway. Here, we report on the rapid …

NMDA (N-methyl-D-aspartate) receptors and calcium can exert multiple and very divergent
effects within neuronal cells, thereby impacting opposing occurrences such as synaptic …

Actin is a versatile and ubiquitous cytoskeletal protein that plays a major role in both the
establishment and the maintenance of neuronal polarity. For a long time, the most prominent …

Most of the excitatory synapses on principal neurons of the forebrain are located on
specialized structures called dendritic spines. Their morphology, comprising a spine head …