[HTML][HTML] Structural Basis for the Inhibition of Histone Deacetylase 8 (HDAC8), a Key Epigenetic Player in the Blood Fluke Schistosoma mansoni
…, S Kannan, AT Hauser, M Moraes Mourão… - PLoS …, 2013 - journals.plos.org
The treatment of schistosomiasis, a disease caused by blood flukes parasites of the Schistosoma
genus, depends on the intensive use of a single drug, praziquantel, which increases …
genus, depends on the intensive use of a single drug, praziquantel, which increases …
[HTML][HTML] Docking-Based Virtual Screening Enables Prioritizing Protein Kinase Inhibitors With In Vitro Phenotypic Activity Against Schistosoma mansoni
…, SG Gava, GP Torres, MM Mourão… - Frontiers in Cellular …, 2022 - frontiersin.org
Schistosomiasis is a parasitic neglected disease with praziquantel (PZQ) utilized as the main
drug for treatment, despite its low effectiveness against early stages of the worm. To aid in …
drug for treatment, despite its low effectiveness against early stages of the worm. To aid in …
[HTML][HTML] A high-throughput colorimetric assay for detection of Schistosoma mansoni viability based on the tetrazolium salt XTT
…, NMGS Fernandes, CL Zani, MM Mourão - Parasites & vectors, 2017 - Springer
Background Schistosoma mansoni is a trematode parasite that causes schistosomiasis, one
of the most prevalent neglected tropical diseases, leading to the loss of 2.6 million disability-…
of the most prevalent neglected tropical diseases, leading to the loss of 2.6 million disability-…
[HTML][HTML] Landscape of the spliced leader trans-splicing mechanism in Schistosoma mansoni
…, NAN Jorge, AM Macedo, CR Machado, MM Mourão… - Scientific Reports, 2018 - nature.com
Spliced leader dependent trans-splicing (SLTS) has been described as an important RNA
regulatory process that occurs in different organisms, including the trematode Schistosoma …
regulatory process that occurs in different organisms, including the trematode Schistosoma …
[HTML][HTML] Schistosoma mansoni FES tyrosine kinase involvement in the mammalian schistosomiasis outcome and miracidia infection capability in Biomphalaria …
…, LC Montresor, RL Caldeira, MM Mourão - Frontiers in …, 2020 - frontiersin.org
Schistosomiasis is a neglected tropical disease (NTD) caused by helminthes from the
Schistosoma genus. This NTD can cause systemic symptoms induced by the deposition of …
Schistosoma genus. This NTD can cause systemic symptoms induced by the deposition of …
[HTML][HTML] Assessment of the accuracy of 11 different diagnostic tests for the detection of Schistosomiasis mansoni in individuals from a Brazilian area of low endemicity …
…, O dos Santos Carvalho, M Moraes Mourão… - Frontiers in …, 2022 - frontiersin.org
Background Schistosomiasis is a parasitic disease associated with poverty. It is estimated
that 7.1 million people are infected with Schistosoma mansoni in Latin America, with 95% of …
that 7.1 million people are infected with Schistosoma mansoni in Latin America, with 95% of …
Schistosomiasis: setting routes for drug discovery
…, SG Gava, G Oliveira, MM Mourão - Special Topics in …, 2016 - books.google.com
Schistosomiasis is the second most prevalent parasitic disease in the world. Currently, the
treatment of this disease relies on a single drug, praziquantel, and due to the identification of …
treatment of this disease relies on a single drug, praziquantel, and due to the identification of …
Distinct patterns of cellular immune response elicited by influenza non-adjuvanted and AS03-adjuvanted monovalent H1N1 (pdm09) vaccine
S Giarola-Silva, JGA Coelho-dos-Reis, MM Mourão… - Antiviral Research, 2017 - Elsevier
The study aimed at identifying biomarkers of immune response elicited by non-adjuvanted-(NAV)
and adjuvanted-(AV) H1N1(pdm09) vaccines. The results showed that despite both …
and adjuvanted-(AV) H1N1(pdm09) vaccines. The results showed that despite both …
Parasitemia evaluation in mice infected with Schistosoma mansoni
NC Tavares, MM Mourão - Bio-protocol, 2021 - bio-protocol.org
Schistosomiasis is a neglected tropical disease. Its treatment relies on the use of a single
drug, praziquantel. Due to treatment limitations, an alternative for schistosomiasis …
drug, praziquantel. Due to treatment limitations, an alternative for schistosomiasis …
[HTML][HTML] Schistosoma mansoni: Off-target analyses using nonspecific double-stranded RNAs as control for RNAi experiments in schistosomula
…, FMG de Araújo, G Oliveira, MM Mourão - Experimental …, 2017 - Elsevier
RNA interference is a well established and widely used reverse genetic tool available for
gene functional studies in trematodes. This technique requires the use of nonrelevant double-…
gene functional studies in trematodes. This technique requires the use of nonrelevant double-…