In response to complement activation, the membrane attack complex (MAC) assembles
from fluid-phase proteins to form pores in lipid bilayers. MAC directly lyses pathogens by a ‘multi-…

MS density map using the MDFF method (Molecular Dynamics Flexible Fitting). The
structure allowed for the identification of ribosome–lipid interactions. The rRNA helix 59 (H59) …

The membrane attack complex (MAC) is one of the immune system’s first responders.
Complement proteins assemble on target membranes to form pores that lyse pathogens and …

The activity of dynein is regulated by a number of adaptors that mediate its interaction with
dynactin, effectively activating the motor complex while also connecting it to different cargos. …

Electron microscopy of frozen hydrated samples (cryo-EM) is a powerful structural
technique that allows the direct study of functional macromolecular complexes in an almost …

The microtubule nucleator γ-tubulin ring complex (γTuRC) is essential for the function of
microtubule organizing centers such as the centrosome. Since its discovery over two decades …

Complement is a key component of innate immunity in health and a powerful driver of
inflammation and tissue injury in disease. The biological and pathological effects of complement …

Colchicine has been used to treat gout and, more recently, to effectively prevents
autoinflammatory diseases and both primary and recurrent episodes of pericarditis. The anti-…

Tubulin proteostasis is regulated by a group of molecular chaperones termed tubulin cofactors
(TBC). Whereas tubulin heterodimer formation is well‐characterized biochemically, its …

Microtubules are essential for intracellular organization and chromosome segregation. They
are nucleated by the γ-tubulin ring complex (γTuRC). However, isolated vertebrate γTuRC …