User profiles for Mario A.A. Pepe
 | Mario PepePrincipal computational biologist, Investigative toxicology Boehringer-Ingelheim Verified email at mail.de Cited by 231 |
Club cells form lung adenocarcinomas and maintain the alveoli of adult mice
10.7554/eLife.45571.001 Lung cancer and chronic lung diseases impose major disease
burdens worldwide and are caused by inhaled noxious agents including tobacco smoke. The …
burdens worldwide and are caused by inhaled noxious agents including tobacco smoke. The …
Prognostic phenotypes of early-stage lung adenocarcinoma
Background Survival after curative resection of early-stage lung adenocarcinoma (LUAD)
varies and prognostic biomarkers are urgently needed. Methods Large-format tissue samples …
varies and prognostic biomarkers are urgently needed. Methods Large-format tissue samples …
KRAS signaling in malignant pleural mesothelioma
Malignant pleural mesothelioma (MPM) arises from mesothelial cells lining the pleural
cavity of asbestos‐exposed individuals and rapidly leads to death. MPM harbors loss‐of‐function …
cavity of asbestos‐exposed individuals and rapidly leads to death. MPM harbors loss‐of‐function …
[HTML][HTML] Non-Oncogene Addiction of KRAS-Mutant Cancers to IL-1β via Versican and Mononuclear IKKβ
Simple Summary Kirsten rat sarcoma virus (KRAS)-mutant cancers are frequent, metastatic,
lethal, and largely undruggable. The aim of this study was to investigate the pathways …
lethal, and largely undruggable. The aim of this study was to investigate the pathways …
Tobacco chemical-induced mouse lung adenocarcinoma cell lines pin the prolactin orthologue proliferin as a lung tumour promoter
Lung adenocarcinoma (LADC) is the leading cause of cancer death worldwide.
Nevertheless, syngeneic mouse models of the disease are sparse, and cell lines suitable for …
Nevertheless, syngeneic mouse models of the disease are sparse, and cell lines suitable for …
[HTML][HTML] Transcriptome signature of miRNA-26b KO mouse model suggests novel targets
EPC van der Vorst, MAA Pepe, LJF Peters… - BMC genomic data, 2021 - Springer
Background MicroRNAs (miRNAs) are short (20–24 nt) non-coding RNAs that are involved
in post-transcriptional regulation of gene expression in multicellular organisms by affecting …
in post-transcriptional regulation of gene expression in multicellular organisms by affecting …
[HTML][HTML] An in vivo inflammatory loop potentiates KRAS blockade
…, D Kati, C Henning, GA Giotopoulou, MAA Pepe… - Biomedicines, 2022 - mdpi.com
KRAS (KRAS proto-oncogene, GTPase) inhibitors perform less well than other targeted drugs
in vitro and fail clinical trials. To investigate a possible reason for this, we treated human …
in vitro and fail clinical trials. To investigate a possible reason for this, we treated human …
Insights into the High-energy γ-ray Emission of Markarian 501 from Extensive Multifrequency Observations in the Fermi Era
…, TJ Pearson, V Pelassa, M Pepe… - The Astrophysical …, 2011 - iopscience.iop.org
Blazars constitute a subclass of radio-loud active galactic nuclei (AGNs), in which a jet of
magnetized plasma assumed to emanate with relativistic bulk velocity from close to a central …
magnetized plasma assumed to emanate with relativistic bulk velocity from close to a central …
Multi-wavelength observations of the flaring gamma-ray blazar 3C 66A in 2008 October
…, JH Panetta, D Parent, V Pelassa, M Pepe… - The Astrophysical …, 2010 - iopscience.iop.org
The radio source 3C 66 (Bennett 1962) was shown by Mackay (1971) and Northover (1973)
to actually consist of two unrelated radio sources separated by 0.◦ 11: a compact source (3C …
to actually consist of two unrelated radio sources separated by 0.◦ 11: a compact source (3C …
An in vivo inflammatory loop potentiates KRAS blockade
…, D Kati, C Henning, GA Giotopoulou, MAA Pepe… - bioRxiv, 2019 - biorxiv.org
KRAS inhibitors perform inferior to other targeted drugs in vitro and fail clinical trials. To
investigate a possible reason for this, we treated human and murine tumor cells with KRAS …
investigate a possible reason for this, we treated human and murine tumor cells with KRAS …