Transcription factors (TFs) regulate gene programs, thereby controlling diverse cellular
processes and cell states. To comprehensively understand TFs and the programs they control, …

Recent success in identifying gene-regulatory elements in the context of recombinant adeno-associated
virus vectors has enabled cell-type-restricted gene expression. However, within …

The thalamic reticular nucleus (TRN), the major source of thalamic inhibition, regulates
thalamocortical interactions that are critical for sensory processing, attention and cognition 1, 2, 3, …

Although the release of mesoaccumbal dopamine is certainly involved in rewarding responses,
recent studies point to the importance of the interaction between it and glutamate. One …

Abstract Models of basal ganglia (BG) function posit a dynamic balance between two
classes of striatal projection neurons (SPNs): direct pathway neurons (dSPNs) that facilitate …

CACNA1I, a schizophrenia risk gene, encodes a subtype of voltage-gated T-type calcium
channel Ca V 3.3. We previously reported that a patient-derived missense de novo mutation (…

The striatum is the largest entrance to the basal ganglia. Diverse neuron classes make up
striatal microcircuit activity, consisting in the sequential activation of neuronal ensembles. How …

Fragile X mental retardation 1 (FMR1) encodes the RNA binding protein FMRP. Loss of FMRP
drives Fragile X syndrome (FXS), the leading inherited cause of intellectual disability and …

Background Previous work showed differences in the polysynaptic activation of GABAergic
synapses during corticostriatal suprathreshold responses in direct and indirect striatal …

Amantadine and clozapine have proved to reduce abnormal involuntary movements (AIMs)
in preclinical and clinical studies of L-DOPA-Induced Dyskinesias (LID). Even though both …