The kinases RIPK1 and RIPK3 and the pseudo-kinase MLKL have been identified as key
regulators of the necroptotic cell death pathway, although a role for MLKL within the whole …

Thrombopoietin (TPO) acting via its receptor, the cellular homologue of the myeloproliferative
leukemia virus oncogene (Mpl), is the major cytokine regulator of platelet number. To …

The lifespan of platelets in circulation is brief, close to 10 days in humans and 5 days in mice.
Bone marrow residing megakaryocytes produce around 100 billion platelets per day. In a …

Polycomb repressive complex 2 (PRC2) is a chromatin modifier that regulates stem cells in
embryonic and adult tissues. Loss-of-function studies of PRC2 components have been …

BH3 mimetic drugs that target BCL-2 family pro-survival proteins to induce tumour cell
apoptosis represent a new era in cancer therapy. Clinical trials of navitoclax (ABT-263, which …

Mature megakaryocytes depend on the function of Bcl-x L , a member of the Bcl-2 family of
prosurvival proteins, to proceed safely through the process of platelet shedding. Despite this, …

The human body produces approximately 100 billion platelets per day. At steady state, only
a small fraction of these are consumed in hemostatic processes. The majority are cleared by …

The circulating life span of blood platelets is regulated by the prosurvival protein BCL-X L . It
restrains the activity of BAK and BAX, the essential prodeath mediators of intrinsic apoptosis…

Platelets have been shown to enhance the survival of lymphoma cell lines. However, it remains
unclear whether they play a role in lymphoma. Here, we investigated the potential role of …

Necroptosis is a pro-inflammatory cell death program executed by the terminal effector, mixed
lineage kinase domain-like (MLKL). Previous studies suggested a role for the necroptotic …