The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macrodomain within
the nonstructural protein 3 counteracts host-mediated antiviral adenosine diphosphate–…

ADP-ribosyltransferases use NAD + to catalyse substrate ADP-ribosylation 1 , and thereby
regulate cellular pathways or contribute to toxin-mediated pathogenicity of bacteria 2 , 3 – 4 . …

ADP-ribosylation has primarily been known as post-translational modification of proteins. As
signalling strategy conserved in all domains of life, it modulates substrate activity, …

Fragment-based drug design has introduced a bottom-up process for drug development, with
improved sampling of chemical space and increased effectiveness in early drug discovery. …

PARP14 is a mono–ADP-ribosyl transferase involved in the control of immunity, transcription,
and DNA replication stress management. However, little is known about the ADP-…

AlphaFold2 and related computational tools have greatly aided studies of structural biology
through their ability to accurately predict protein structures. In the present work, we explored …

The nonstructural protein 3 (NSP3) of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2)
contains a conserved macrodomain enzyme (Mac1) that is critical for …

PARP1, an established anti-cancer target that regulates many cellular pathways, including
DNA repair signaling, has been intensely studied for decades as a poly(ADP-ribosyl)…

Viral macrodomains possess the ability to counteract host ADP-ribosylation, a post-translational
modification implicated in the creation of an antiviral environment via immune response …

Conversion of vitamin B 12 (cobalamin, Cbl) into the cofactor forms methyl-Cbl (MeCbl) and
adenosyl-Cbl (AdoCbl) is required for the function of two crucial enzymes, mitochondrial …