CD4 + T cells and CD4 + chimeric antigen receptor (CAR) T cells display highly variable
antitumor activity in preclinical models and in patients; however, the mechanisms dictating how …

The goal of this review is to pinpoint the specific features, including the weaknesses, of
various tumor models, and to discuss the reasons why treatments that are efficient in murine …

It is well established that tumor-associated macrophages (TAM) found in most advanced
tumors have a pro-tumoral role. In this context, TAM limit the activity of tumor-infiltrating …

Regressing tumors are usually associated with a large immune infiltrate, but the molecular
and cellular interactions that govern a successful anti-tumor immunity remain elusive. Here, …

Type I interferons (IFN) are being rediscovered as potent anti-tumoral agents. Activation of the
STimulator of INterferon Genes (STING) by DMXAA (5,6-dimethylxanthenone-4-acetic acid…

Simple Summary Innate and adaptive immunity mutually regulate one another in a dynamic
fashion during immune responses. In infectious contexts, positive interactions between …

Anti-PD-1 therapy targets intratumoral CD8+ T cells to promote clinical responses in cancer
patients. Recent evidence suggests an additional activity in the periphery, but the underlying …

Background Tumor relapse constitutes a major challenge for anti-tumoral treatments, including
immunotherapies. Indeed, most cancer-related deaths occur during the tumor relapse …

Type I interferons (IFN) are being rediscovered as potent anti-tumoral agents. Activation of
the STimulator of INterferon Genes (STING) by DMXAA can induce a strong production of IFN …

A new class of malolactonate polymers and copolymers were synthesized, starting from the
corresponding lactones, and then characterized. Different lateral groups were selected for …