In addition to its role in controlling cell cycle progression, the tumor suppressor protein p53
can also affect other cellular functions such as cell migration. In this study, we show that p53 …

GTPases of the Rho family control a wide variety of cellular processes such as cell morphology,
motility, proliferation, differentiation, and apoptosis. We report here the characterization …

Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder phenotypically
characterized by many features of premature aging. Most cases of HGPS are due to a …

Genotoxicants have been used for decades as front-line therapies against cancer on the
basis of their DNA-damaging actions. However, some of their non-DNA-damaging effects are …

10.7554/eLife.14734.001 TP53 is conventionally thought to prevent cancer formation and
progression to metastasis, while mutant TP53 has transforming activities. However, in the clinic…

… Marion de Toledo Marion de Toledo Institut de Génétique Moléculaire de Montpellier,
CNRS UMR 5535, Universities of Montpellier 1 and Montpellier 2, Montpellier, France …

Rho GTPases are key regulators of tumour cell invasion and therefore constitute attractive
targets for the design of anticancer agents. Several strategies have been developed to …

Resistance to chemotherapeutic drugs is a major cause of treatment failure in acute myeloid
leukemias (AML). To better characterize the mechanisms of chemoresistance, we first …

Alternative splicing is a key molecular mechanism for increasing the complexity of the
human transcriptome. Nearly all human genes are regulated by alternative splicing and the …

Rho GTPases are key regulators of actin dynamics. We report that the Rho GTPase TCL,
which is closely related to Cdc42 and TC10, localizes to the plasma membrane and the early/…