Ulcerative colitis and Crohn’s disease are forms of inflammatory bowel disease whose
incidence and prevalence are increasing worldwide. These diseases lead to chronic …

The effects of lysine N ε -trimethylation at selected positions of the antimicrobial cecropin A−melittin
hybrid peptide KWKLFKKIGAVLKVL-amide have been studied. All five …

The majority of current cancer therapies are aimed at reducing tumour growth, but there is
lack of viable pharmacological options to reduce the formation of metastasis. This is a paradox…

Teriparatide is an anabolic peptide drug indicated for the treatment of osteoporosis.
Recombinant teriparatide was first approved in 2002 and has since been followed by patent-free …

Somatostatin is a 14-residue peptide hormone that regulates the endocrine system by binding
to five G-protein-coupled receptors (SSTR1–5). We have designed six new Somatostatin …

Small-molecule microarrays are often limited by the requirement for each compound undergoing
immobilization to contain a common functional group or by the need to prepare glass …

Ulcerative colitis and Crohn’s disease are inflammatory bowel diseases (IBD) that lead to
chronic inflammations of the gastrointestinal tract due to an abnormal response of the immune …

Photophores are stable reagents that become highly reactive species when activated by UV
light, often forming new covalent bonds with surrounding molecules. These may be …

The use of high quality starting materials in SPPS is a prerequisite to obtain peptides of high
purity and with high yields [1]. Beside AA derivatives and reagents, the quality of employed …

Peptide self-assembly processes are central to the etiology of amyloid diseases [1]. Much
effort has been devoted to characterizing amyloid structure and the mechanisms of peptide …