Previous genome-wide association studies (GWASs) of stroke — the second leading cause
of death worldwide — were conducted predominantly in populations of European ancestry 1 …

Decades of research have established atherosclerosis as an inflammatory disease. Only
recently though, clinical trials provided proof-of-concept evidence for the efficacy of anti-…

Drugs whose targets have genetic evidence to support efficacy and safety are more likely to
be approved after clinical development. In this paper, we provide an overview of how natural …

Importance Observational studies highlight associations of C-reactive protein (CRP), a general
marker of inflammation, and interleukin 6 (IL-6), a cytokine-stimulating CRP production, …

Importance Estrogens have neuroprotective and antidepressive effects; however,
associations between indices of reduced endogenous estrogens and risk for postmenopausal …

Background: Cytokines and growth factors have been implicated in the initiation and propagation
of vascular disease. Observational studies have shown associations of their circulating …

Objective To investigate the relationship between baseline white matter hyperintensities (WMH)
in patients with ischemic stroke and long-term risk of dementia, functional impairment, …

Introduction Midlife clustering of vascular risk factors has been associated with late‐life
dementia, but causal effects of individual biological and lifestyle factors remain largely unknown. …

Introduction Experimental and epidemiological studies suggest female sex hormones to have
long-lasting neuroprotective and anti-ageing properties. Surgically-induced menopause …

Women have a lifetime risk of major depression double that of men but only during their
reproductive years. This sex difference has been attributed partially to activational effects of …