Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine
…, S Raghavan, J Kim, LK Brais, D Ragon, MW Welch… - Cancer discovery, 2018 - AACR
Clinically relevant subtypes exist for pancreatic ductal adenocarcinoma (PDAC), but molecular
characterization is not yet standard in clinical care. We implemented a biopsy protocol to …
characterization is not yet standard in clinical care. We implemented a biopsy protocol to …
Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer
Purpose Germline variants in double-strand DNA damage repair (dsDDR) genes (eg,
BRCA1/2) predispose to pancreatic adenocarcinoma (PDAC) and may predict sensitivity to …
BRCA1/2) predispose to pancreatic adenocarcinoma (PDAC) and may predict sensitivity to …
Association of alterations in main driver genes with outcomes of patients with resected pancreatic ductal adenocarcinoma
…, MW Welch, LK Brais, A Da Silva, T Li, W Li… - JAMA …, 2018 - jamanetwork.com
Importance Although patients with resected pancreatic adenocarcinoma are at high risk for
disease recurrence, few biomarkers are available to inform patient outcomes. Objective To …
disease recurrence, few biomarkers are available to inform patient outcomes. Objective To …
Altered exocrine function can drive adipose wasting in early pancreatic cancer
Malignancy is accompanied by changes in the metabolism of both cells and the organism 1
, 2 . Pancreatic ductal adenocarcinoma (PDAC) is associated with wasting of peripheral …
, 2 . Pancreatic ductal adenocarcinoma (PDAC) is associated with wasting of peripheral …
[HTML][HTML] Lymph node metastases in resected pancreatic ductal adenocarcinoma: predictors of disease recurrence and survival
…, JA Nowak, N Khalaf, LK Brais, MW Welch… - British journal of …, 2017 - nature.com
Background: Few studies have simultaneously assessed the prognostic value of the
multiple classification systems for lymph node (LN) metastases in resected pancreatic ductal …
multiple classification systems for lymph node (LN) metastases in resected pancreatic ductal …
Postdiagnosis loss of skeletal muscle, but not adipose tissue, is associated with shorter survival of patients with advanced pancreatic cancer
…, N Khalaf, RF Dunne, LK Brais, MW Welch… - … Biomarkers & Prevention, 2019 - AACR
Background: Pancreatic cancer is associated with development of cachexia, a wasting
syndrome thought to limit survival. Few studies have longitudinally quantified peripheral tissues …
syndrome thought to limit survival. Few studies have longitudinally quantified peripheral tissues …
Genetic and circulating biomarker data improve risk prediction for pancreatic cancer in the general population
…, PV Pandharipande, LK Brais, MW Welch… - … Biomarkers & Prevention, 2020 - AACR
Background: Pancreatic cancer is the third leading cause of cancer death in the United
States, and 80% of patients present with advanced, incurable disease. Risk markers for …
States, and 80% of patients present with advanced, incurable disease. Risk markers for …
Bead‐Based Extracellular Vesicle Analysis Using Flow Cytometry
KS Yang, HY Lin, C Curley, MW Welch… - Advanced …, 2020 - Wiley Online Library
Extracellular vesicles (EVs) represent promising circulating biomarkers for cancers, but their
high‐throughput analyses in clinical settings prove challenging due to lack of simple, fast, …
high‐throughput analyses in clinical settings prove challenging due to lack of simple, fast, …
Bead Enhancement of EV Analysis
Extracellular vesicles (EVs) are recognized cancer biomarkers, however, clinical analysis
has been difficult due to a lack of simple and sensitive assays. Here, we describe a bead-…
has been difficult due to a lack of simple and sensitive assays. Here, we describe a bead-…
Absolute risk prediction models for pancreatic cancer
J Kim, C Yuan, A Babic, Y Bao, LK Brais, MW Welch… - Cancer Research, 2018 - AACR
Introduction: Pancreatic cancer is one of the leading causes of cancer deaths in Western
countries and has a 5-year survival rate of less than 10% as a high proportion of patients are …
countries and has a 5-year survival rate of less than 10% as a high proportion of patients are …