Overexpressing corticotropin-releasing factor in the primate amygdala increases anxious temperament and alters its neural circuit
Background Nonhuman primate models are critical for understanding mechanisms
underlying human psychopathology. We established a nonhuman primate model of anxious …
underlying human psychopathology. We established a nonhuman primate model of anxious …
Gene expression in the primate orbitofrontal cortex related to anxious temperament
…, JA Oler, PH Roseboom, MK Riedel… - Proceedings of the …, 2023 - National Acad Sciences
Anxiety disorders are among the most prevalent psychiatric disorders, causing significant
suffering and disability. Relative to other psychiatric disorders, anxiety disorders tend to …
suffering and disability. Relative to other psychiatric disorders, anxiety disorders tend to …
[HTML][HTML] Evidence in primates supporting the use of chemogenetics for the treatment of human refractory neuropsychiatric disorders
…, SAL Mueller, JA Oler, AS Fox, MK Riedel… - Molecular Therapy, 2021 - cell.com
Non-human primate (NHP) models are essential for developing and translating new treatments
that target neural circuit dysfunction underlying human psychopathology. As a proof-of-…
that target neural circuit dysfunction underlying human psychopathology. As a proof-of-…
Dorsal amygdala neurotrophin-3 decreases anxious temperament in primates
…, JMH Kim, J Nguyen, DA French, MK Riedel… - Biological …, 2019 - Elsevier
Background An early-life anxious temperament (AT) is a risk factor for the development of
anxiety, depression, and comorbid substance abuse. We validated a nonhuman primate …
anxiety, depression, and comorbid substance abuse. We validated a nonhuman primate …
Transcriptional profiling of primate central nucleus of the amygdala neurons to understand the molecular underpinnings of early-life anxious temperament
…, CE Goss, PH Roseboom, JA Oler, MK Riedel… - Biological …, 2020 - Elsevier
Background Children exhibiting extreme anxious temperament (AT) are at an increased risk
for developing anxiety and depression. Our previous mechanistic and neuroimaging work in …
for developing anxiety and depression. Our previous mechanistic and neuroimaging work in …
[HTML][HTML] Prefrontal influences on the function of the neural circuitry underlying anxious temperament in primates
Anxious temperament, characterized by heightened behavioral and physiological reactivity
to potential threat, is an early childhood risk factor for the later development of stress-related …
to potential threat, is an early childhood risk factor for the later development of stress-related …
[HTML][HTML] The Neurobiology of Stress: Vulnerability, Resilience, and Major Depression: Gene expression in the primate orbitofrontal cortex related to anxious …
…, JA Oler, PH Roseboom, MK Riedel… - Proceedings of the …, 2023 - ncbi.nlm.nih.gov
Methods AT Phenotyping. AT is assessed using a 30-min exposure to the no eye contact (NEC)
condition of the human intruder paradigm (HIP)(Fig. 1A). Duration of freezing and …
condition of the human intruder paradigm (HIP)(Fig. 1A). Duration of freezing and …
A preliminary study of the effects of an antimuscarinic agent on anxious behaviors and white matter microarchitecture in nonhuman primates
…, DPM Tromp, PH Roseboom, MK Riedel… - …, 2024 - nature.com
Myelination subserves efficient neuronal communication, and alterations in white matter (WM)
microstructure have been implicated in numerous psychiatric disorders, including …
microstructure have been implicated in numerous psychiatric disorders, including …
Early life adversity in primates: Behavioral, endocrine, and neural effects
Background Evidence suggests that early life adversity is associated with maladaptive
behaviors and is commonly an antecedent of stress-related psychopathology. This is particularly …
behaviors and is commonly an antecedent of stress-related psychopathology. This is particularly …
Real-time intraoperative MRI intracerebral delivery of induced pluripotent stem cell-derived neurons
Induced pluripotent stem cell (iPSC)-derived neurons represent an opportunity for cell
replacement strategies for neurodegenerative disorders such as Parkinson's disease (PD). …
replacement strategies for neurodegenerative disorders such as Parkinson's disease (PD). …