Intracellular protozoan parasites are potent stimulators of cell-mediated immunity. The
induction of macrophage proinflammatory cytokines by Trypanosoma cruzi is considered to be …

Components of Trypanosoma cruzi able to induce the production of IL-12 and other proinflammatory
cytokines by macrophages were identified. Murine inflammatory macrophages were …

In the present study, we investigated the role of glycosylphosphatidylinositol-anchored
mucin-like glycoproteins (GPI-mucins) from Trypanosoma cruzi trypomastigotes in triggering the …

Common variable immunodeficiency (CVID) is an immunological disorder characterized by
defective antibody production, recurrent infections, most notably of the respiratory tract, …

Limb-girdle muscular dystrophies (LGMDs) are a heterogeneous group of disorders characterized
by progressive degeneration of skeletal muscle caused by the absence of or defective …

Background The unfolded protein response (UPR) is one of the pathways triggered to
ensure quality control of the proteins assembled in the endoplasmic reticulum (ER) when cell …

Microbial stimuli such as bacterial lipopolysaccharide (LPS) or glycosylphosphatidylinositol‐mucins
derived from Trypanosoma cruzi trypomastigotes (tGPI‐mucins) are effective …

Fever is a regulated increase of the body temperature resulting from both infectious and non-infectious
causes. Fever is known to play a role in modulating immune responses to …

Common variable immunodeficiency (CVID) is a primary immunodeficiency characterized
by hypogammaglobulinemia and recurrent infections. Herein we addressed the role of …

Engagement of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) is a master trigger of
the deleterious effects of septic shock. Horses and humans are considered the most …