L-leucyl-L-leucine methyl ester (LLOMe) induces apoptosis, which is thought to be mediated
by release of lysosomal cysteine cathepsins from permeabilized lysosomes into the cytosol. …

The intracellular movement and positioning of organelles and vesicles is mediated by the
cytoskeleton and molecular motors. Small GTPases like Rab and Arf proteins are main …

Rab GTPases are key regulators of intracellular trafficking, and cycle between a GTP-bound
active state and a GDP-bound inactive state. This cycle is regulated by guanine-nucleotide …

Lysosomal signaling facilitates the migration of immune cells by releasing Ca 2+ to activate
the actin-based motor myosin II at the cell rear. However, how the actomyosin cytoskeleton …

Rab9 is a small GTPase that localizes to the trans‐Golgi Network ( TGN ) and late
endosomes. Its main function has long been connected to the recycling of mannose‐6‐phosphate …

Autophagy (macroautophagy) is a highly conserved eukaryotic degradation pathway in
which cytosolic components and organelles are sequestered by specialized autophagic …

Background Patient and public involvement (PPI) in health research may improve both the
relevance and quality of the research. There is however a lack of research investigating the …

Rab proteins are master regulators of intracellular membrane trafficking, but they also
contribute to cell division, signaling, polarization, and migration. The majority of the works …

Rab proteins are small GTPases essential for controlling and coordinating intracellular traffic.
The small GTPase Rab7b regulates the retrograde transport from late endosomes toward …

… Marita Borg Distefano is the first author on ‘ TBC1D5 controls the GTPase cycle of Rab7b
’, published in Journal of Cell Science. Marita is a researcher in the labs of Oddmund Bakke …