Latent membrane protein 1 (LMP1) of Epstein–Barr virus (EBV) is an integral membrane
protein which has transforming potential and is necessary but not sufficient for B‐cell …

Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) have been recently identified in
families with autosomal dominant late-onset Parkinson disease (PD). The LRRK2 protein …

Purpose Age-related macular degeneration (AMD) is a frequent, complex disorder in elderly
of European ancestry. Risk profiles and treatment options have changed considerably over …

Latent membrane protein 1 (LMP1) acts like a permanently activated receptor of the tumor
necrosis factor (TNF)‐receptor superfamily and is absolutely required for B cell …

Reactive oxygen species (ROS) play an important role in cell death induced by many different
stimuli. This study shows that hydrogen peroxide-induced apoptosis in T-cells did not …

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the single most common cause of
inherited Parkinson's disease. Little is known about its involvement in the pathogenesis of …

The Epstein–Barr virus latent membrane protein‐1 (LMP‐1) is an integral membrane protein
which transforms fibroblasts and is essential for EBV‐mediated B‐cell immortalization. LMP‐…

10.7554/eLife.46188.001 The devastating effects and incurable nature of hereditary and
sporadic retinal diseases such as Stargardt disease, age-related macular degeneration or …

Isolation and dissection of native multiprotein complexes is a central theme in functional
genomics. The development of the tandem affinity purification (TAP) tag has enabled an efficient …

Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic
disorders. We describe a whole-genome siRNA-based reverse genetics screen for defects in …