User profiles for Marius Walter
 | Marius WalterStaff Scientist, Fred Hutch Cancer Center, Seattle. Verified email at fredhutch.org Cited by 711 |
An epigenetic switch ensures transposon repression upon dynamic loss of DNA methylation in embryonic stem cells
10.7554/eLife.11418.001 DNA methylation is extensively remodeled during mammalian
gametogenesis and embryogenesis. Most transposons become hypomethylated, raising the …
gametogenesis and embryogenesis. Most transposons become hypomethylated, raising the …
DNA methylation restrains transposons from adopting a chromatin signature permissive for meiotic recombination
DNA methylation is essential for protecting the mammalian germline against transposons.
When DNA methylation-based transposon control is defective, meiotic chromosome pairing is …
When DNA methylation-based transposon control is defective, meiotic chromosome pairing is …
[HTML][HTML] Characterising proteolysis during SARS-CoV-2 infection identifies viral cleavage sites and cellular targets with therapeutic potential
SARS-CoV-2 is the causative agent behind the COVID-19 pandemic, responsible for over
170 million infections, and over 3.7 million deaths worldwide. Efforts to test, treat and …
170 million infections, and over 3.7 million deaths worldwide. Efforts to test, treat and …
Transient transcription in the early embryo sets an epigenetic state that programs postnatal growth
The potential for early embryonic events to program epigenetic states that influence adult
physiology remains an important question in health and development. Using the imprinted …
physiology remains an important question in health and development. Using the imprinted …
[HTML][HTML] SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein
SARS-CoV-2 non-structural protein Nsp14 is a highly conserved enzyme necessary for viral
replication. Nsp14 forms a stable complex with non-structural protein Nsp10 and exhibits …
replication. Nsp14 forms a stable complex with non-structural protein Nsp10 and exhibits …
DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation
…, J Iranzo, F El Marjou, P Gestraud, M Walter… - Nature Structural & …, 2024 - nature.com
As embryonic stem cells (ESCs) transition from naive to primed pluripotency during early
mammalian development, they acquire high DNA methylation levels. During this transition, the …
mammalian development, they acquire high DNA methylation levels. During this transition, the …
FOXO1 promotes HIV latency by suppressing ER stress in T cells
Quiescence is a hallmark of CD4 + T cells latently infected with human immunodeficiency
virus 1 (HIV-1). While reversing this quiescence is an effective approach to reactivate latent …
virus 1 (HIV-1). While reversing this quiescence is an effective approach to reactivate latent …
[HTML][HTML] Coenzyme A binding sites induce proximal acylation across protein families
Lysine Nɛ-acylations, such as acetylation or succinylation, are post-translational modifications
that regulate protein function. In mitochondria, lysine acylation is predominantly non-…
that regulate protein function. In mitochondria, lysine acylation is predominantly non-…
[HTML][HTML] Viral gene drive in herpesviruses
Gene drives are genetic modifications designed to propagate in a population with high
efficiency. Current gene drive strategies rely on sexual reproduction and are thought to be …
efficiency. Current gene drive strategies rely on sexual reproduction and are thought to be …
Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage sites and cellular targets with therapeutic potential
SARS-CoV-2 is the causative agent behind the COVID-19 pandemic, and responsible for
over 100 million infections, and over 2 million deaths worldwide. Efforts to test, treat and …
over 100 million infections, and over 2 million deaths worldwide. Efforts to test, treat and …