Small RNAs are on the move

DH Chitwood, MCP Timmermans - Nature, 2010 - nature.com
A key feature of RNA interference is its ability to spread from cell to cell. Such non-cell-autonomous
gene silencing has been characterized extensively in both plants and animals, but …

microRNA-mediated repression of rolled leaf1 specifies maize leaf polarity

…, JS Kui, J Thomas, BA Heller, MCP Timmermans - Nature, 2004 - nature.com
In both animals and plants, many developmentally important regulatory genes have
complementary microRNAs (miRNAs), which suggests that these miRNAs constitute a class of …

[PDF][PDF] Spatiotemporal developmental trajectories in the Arabidopsis root revealed using high-throughput single-cell RNA sequencing

…, S Klesen, E Scacchi, K Nieselt, MCP Timmermans - Developmental cell, 2019 - cell.com
High-throughput single-cell RNA sequencing (scRNA-seq) is becoming a cornerstone of
developmental research, providing unprecedented power in understanding dynamic processes…

Signals and prepatterns: new insights into organ polarity in plants

…, Y Plavskin, MCP Timmermans - Genes & …, 2009 - genesdev.cshlp.org
The flattening of leaves results from the interaction between upper (adaxial) and lower (abaxial)
domains in the developing primordium. These domains are specified by conserved, …

Establishing leaf polarity: the role of small RNAs and positional signals in the shoot apex

…, M Guo, FTS Nogueira, MCP Timmermans - 2007 - journals.biologists.com
The flattening of leaves results from the juxtaposition of upper (adaxial)and lower (abaxial)
domains in the developing leaf primordium. The adaxial-abaxial axis reflects positional …

[HTML][HTML] Genome-wide discovery and characterization of maize long non-coding RNAs

…, MJ Scanlon, J Yu, PS Schnable, MCP Timmermans… - Genome biology, 2014 - Springer
Background Long non-coding RNAs (lncRNAs) are transcripts that are 200 bp or longer, do
not encode proteins, and potentially play important roles in eukaryotic gene regulation. …

Pattern formation via small RNA mobility

…, JC Carrington, MCP Timmermans - Genes & …, 2009 - genesdev.cshlp.org
MicroRNAs and trans-acting siRNAs (ta-siRNAs) have important regulatory roles in
development. Unlike other developmentally important regulatory molecules, small RNAs are not …

ROUGH SHEATH2: a Myb protein that represses knox homeobox genes in maize lateral organ primordia

MCP Timmermans, A Hudson, PW Becraft, T Nelson - Science, 1999 - JSTOR
The regulation of members of the knotted1-like homeobox (knox) gene family is required for
the normal initiation and development of lateral organs. The maize rough sheath2 (rs2) gene…

Direct Repression of KNOX Loci by the ASYMMETRIC LEAVES1 Complex of Arabidopsis

M Guo, J Thomas, G Collins, MCP Timmermans - The Plant Cell, 2008 - academic.oup.com
KNOTTED1-like homeobox (KNOX) genes promote stem cell activity and must be repressed
to form determinate lateral organs. Stable KNOX gene silencing during organogenesis is …

Two small regulatory RNAs establish opposing fates of a developmental axis

…, MT Juarez, MCP Timmermans - Genes & …, 2007 - genesdev.cshlp.org
Small RNAs are important regulators of gene expression. In maize, adaxial/abaxial (dorsoventral)
leaf polarity is established by an abaxial gradient of microRNA166 (miR166), which …