The mammalian target of rapamycin (MTOR) protein kinase complex is a key component of
a pathway that regulates cell growth and proliferation in response to energy levels, hypoxia, …

Mitochondrial calcium has been postulated to regulate a wide range of processes from
bioenergetics to cell death. Here, we characterize a mouse model that lacks expression of the …

Background: The healthy vascular endothelium, which forms the barrier between blood and
the surrounding tissues, is known to efficiently respond to stress signals like hypoxia and …

Protein GlcNAcylation serves as a nutrient/stress sensor to modulate the functions of many
nuclear and cytoplasmic proteins. O-GlcNAc cycles on serine or threonine residues like …

Long non-coding RNAs (lncRNAs) constitute a significant portion of mammalian genome,
yet the physiological importance of lncRNAs is largely unknown. Here, we identify a liver-…

For metastasis to occur cells must communicate with to their local environment to initiate
growth and invasion. Exosomes have emerged as an important mediator of cell-to-cell …

Energy metabolism is a key aspect of cardiomyocyte biology. Human induced pluripotent stem
cell-derived cardiomyocytes (hiPSC-CMs) are a promising tool for biomedical application, …

Rationale: Redox modifications play an important role in many cellular processes, including
cell death. Ischemic preconditioning (IPC) has been shown to involve redox signaling. …

Although initially viewed as unregulated, increasing evidence suggests that cellular necrosis
often proceeds through a specific molecular program. In particular, death ligands such as …

Succinylation refers to modification of lysine residues with succinyl groups donated by
succinyl-CoA. Sirtuin5 (Sirt5) is a mitochondrial NAD + -dependent deacylase that catalyzes the …