Positive-strand RNA viruses, a large group including human pathogens such as SARS-coronavirus
(SARS-CoV), replicate in the cytoplasm of infected host cells. Their replication …

Coronaviruses are pathogens with a serious impact on human and animal health. They mostly
cause enteric or respiratory disease, which can be severe and life threatening, eg, in the …

Abstract Development of effective preventative interventions against SARS-CoV-2, the
etiologic agent of COVID-19 is urgently needed. The viral surface spike (S) protein of SARS-CoV-…

The sudden emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
at the end of 2019 from the Chinese province of Hubei and its subsequent pandemic spread …

The ubiquitin system plays an important role in endoplasmic reticulum (ER)-associated
degradation of proteins that are misfolded, that fail to associate with their oligomerization partners…

Arteriviruses are positive-stranded RNA viruses that infect mammals. They can cause
persistent or asymptomatic infections, but also acute disease associated with a respiratory …

Ubiquitin (Ub) and interferon-stimulated gene product 15 (ISG15) reversibly conjugate to
proteins and mediate important innate antiviral responses. The ovarian tumor (OTU) domain …

The impact of respiratory virus infections on the health of children and adults can be very
significant. Yet, in contrast to most other childhood infections as well as other viral and bacterial …

Misfolded proteins are eliminated from the endoplasmic reticulum (ER) by retrotranslocation
into the cytosol, a pathway hijacked by certain viruses to destroy MHC class I heavy chains. …

Positive-sense single-stranded RNA (+ssRNA) viruses comprise many (re-)emerging human
pathogens that pose a public health problem. Our innate immune system and, in particular, …