Mammalian lungs are branched networks containing thousands to millions of airways arrayed
in intricate patterns that are crucial for respiration. How such trees are generated during …

Although single-cell RNA sequencing studies have begun to provide compendia of cell
expression profiles 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 – 9 , it has been difficult to systematically identify and …

The mammalian lung is a highly branched network in which the distal regions of the bronchial
tree transform during development into a densely packed honeycomb of alveolar air sacs …

Molecular genetic studies of Drosophila melanogaster have led to profound advances in
understanding the regulation of development. Here we report gene expression patterns for …

Molecular characterization of cell types using single-cell transcriptome sequencing is
revolutionizing cell biology and enabling new insights into the physiology of human organs. We …

Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions. …

Alveoli are gas-exchange sacs lined by squamous alveolar type (AT) 1 cells and cuboidal,
surfactant-secreting AT2 cells. Classical studies suggested that AT1 arise from AT2 cells, but …

Antagonists of several growth factor signaling pathways play important roles in developmental
patterning by limiting the range of the cognate inducer. Here, we describe an antagonist …

We have created a compendium of single cell transcriptomic data from the model organism
Mus musculus comprising more than 100,000 cells from 20 organs and tissues. These data …

Many organs are composed of epithelial tubes that transport vital fluids. Such tubular organs
develop in many different ways and generate tubes of widely varying sizes and structures, …