There is substantial heterogeneity among primary prostate cancers, evident in the spectrum
of molecular abnormalities and its variable clinical course. As part of The Cancer Genome …

Structural variants are implicated in numerous diseases and make up the majority of varying
nucleotides among human genomes. Here we describe an integrated set of eight structural …

The human and mouse genomes contain instructions that specify RNAs and proteins and
govern the timing, magnitude, and cellular context of their production. To better delineate these …

Prostate cancer is the second most common cause of male cancer deaths in the United
States. However, the full range of prostate cancer genomic alterations is incompletely …

Transcription factors bind in a combinatorial fashion to specify the on-and-off states of genes;
the ensemble of these binding events forms a regulatory network, constituting the wiring …

Structural variation of the genome involves kilobase- to megabase-sized deletions, duplications,
insertions, inversions, and complex combinations of rearrangements. We introduce high…

Genome-sequencing studies indicate that all humans carry many genetic variants predicted
to cause loss of function (LoF) of protein-coding genes, suggesting unexpected redundancy …

The anatomical and functional architecture of the human brain is mainly determined by prenatal
transcriptional processes. We describe an anatomically comprehensive atlas of the mid-…

We systematically generated large-scale data sets to improve genome annotation for the
nematode Caenorhabditis elegans, a key model organism. These data sets include …

Genomic structural variants (SVs) are abundant in humans, differing from other forms of
variation in extent, origin and functional impact. Despite progress in SV characterization, the …