Age-related macular degeneration and other macular diseases result in the loss of light-sensing
cone photoreceptors, causing irreversible sight impairment. Photoreceptor replacement …

Defects in the photoreceptor-specific gene encoding aryl hydrocarbon receptor-interacting
protein-like 1 (AIPL1) are clinically heterogeneous and present as Leber Congenital …

Recombinant adeno-associated viruses (AAVs) are popular in vivo gene transfer vehicles.
However, vector doses needed to achieve therapeutic effect are high and some target tissues …

Neuronal communication is typically mediated via synapses and gap junctions. New forms
of intercellular communication, including nanotubes (NTs) and extracellular vesicles (EVs), …

Gliosis is a complex process comprising upregulation of intermediate filament (IF) proteins,
particularly glial fibrillary acidic protein (GFAP) and vimentin, changes in glial cell …

The neuronal ceroid lipofuscinoses (NCLs), more commonly referred to as Batten disease,
are a group of inherited lysosomal storage disorders that present with neurodegeneration, …

Young Rpe65-deficient dogs have been used as a model for human RPE65 Leber congenital
amaurosis (RPE65-LCA) in proof-of-concept trials of recombinant adeno-associated virus (…

Corneal epithelial dystrophies are typically characterized by symptoms such as pain, light
sensitivity, and corneal opacification leading to impaired vision. The development of gene …

The retinal pigment epithelium (RPE) interacts closely with photoreceptors to maintain visual
function. In degenerative diseases such as Stargardt disease and age-related macular …

Purpose: Endothelial cell density (ECD) is the principal factor determining the success of
corneal transplants. Here we explored a strategy to increase corneal ECD in human explants …