The particle fabrication technique PRINT® was used to fabricate monodisperse size and shape
specific poly(lactide-co-glycolide) particles loaded with the chemotherapeutic Docetaxel. …

A meta-analysis was conducted to evaluate the inter-patient pharmacokinetic (PK) variability
of liposomal and small molecule (SM) anticancer agents. Inter-patient PK variability of 9 …

Purpose: To evaluate the pharmacokinetics and tissue disposition of macromolecular
camptothecin (CPT) drug conjugate, XMT-1001, and irinotecan (CPT-11) in mice bearing HT-29 …

Adrenocortical carcinoma (ACC) is an aggressive malignancy with poor response to
chemotherapy. In this study, we evaluated a potential new treatment target for ACC, focusing on the …

Activation of nuclear factor (NF)-κB is mediated by signal-induced phosphorylation of IκBα,
subsequent IκBα degradation, and then translocation of unbound NF-κB to the nucleus. …

BACKGROUND: The management of chronic empyema associated with a bronchopleural
fistula can be a particularly challenging problem. Successful eradication may not occur …

Background: Plastic surgeons are increasingly involved in the repair of complex ventral
hernias. Although this typically involves recurrent incisional hernias, operative strategies can be …

Experimental procedures for preparing RNA-seq and single-cell (sc) RNA-seq libraries are
based on assumptions regarding their underlying enzymatic reactions. Here, we show that …

Background Transcription in mammalian cells is a complex stochastic process involving
shuttling of polymerase between genes and phase-separated liquid condensates. It occurs in …

Opinion statement Despite an explosion in the number of options available for helping diabetic
patients heal wounds, major amputation remains a critical issue for these persons. Since …